25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of {(S)-6-[(R)-7-fluoro-4-(4-hydroxy-phenoxy)-indan-1 -yloxy]-2,3-dihydro- benzofu ra n-3-yl}-acetic acid methyl ester (60 mg), toluene-4-su lfon ic acid 2-methoxy- ethyl ester (34 mg), and cesium carbonate (60 mg) in N,N-dimethylformamide (2 mL) is stirred for 1.5 h at 6000. After cooling to room temperature, the mixture is dilutedwith water an extracted with ethyl acetate. The combined extracts are washed with brine, dried (MgSO4), and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 80:20-*60:40) to give the title compound. The title compound is prepared from {(S)-6-[(R)-4-(4-cyano-3-hydroxy-phenoxy)-7- fluoro-indan-1 -yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4- bromo-tetrahydropyran following a procedure analogous to that described forIntermediate 8. The crude product is used for the next reaction step without further purification.
25637-16-5, The synthetic route of 25637-16-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; LANGKOPF, Elke; WAGNER, Holger; WO2014/86712; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics