Downstream synthetic route of 344329-76-6

As the paragraph descriping shows that 344329-76-6 is playing an increasingly important role.

344329-76-6, Tetrahydro-2H-pyran-4-carboxamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 67 (3 g, 23.23 mmol) , Lawson’s reagent (4.7 g, 11.61 mmol) was added to a round bottom flask containing 50 mL of anhydrous tetrahydrofuran, protected with nitrogen, and stirred at 60 for 14 h. LCMS monitoring, after the reaction was completed, quenched with saturated sodium bicarbonate solution (100 mL) , extracted with EtOAc (200 mL ¡Á 2) , and the combined extracts were washed with saturated aqueous sodium chloride (50 mL) , dried with anhydrous Na 2SO 4, concentrated under reduced pressure, and then purified by column chromatography (eluent: dichloromethane/methanol, 10/1, v/v) , obtained 2 g of a white soild, yield: 59.3%. 1HNMR (400 MHz, DMSO-d 6) : delta ppm 1.55-1.59 (m, 2H) , 1.70-1.81 (m, 2H) , 2.68-2.76 (m, 1H) , 3.30-3.34 (m, 2H) , 3.86-3.90 (m, 2H) , 9.10 (s, 1H) , 9.40 (s, 1H) . LCMS: Rt = 1.01 min, MS Calcd.: 145.2, MS Found: 145.9 [M+H], 344329-76-6

As the paragraph descriping shows that 344329-76-6 is playing an increasingly important role.

Reference£º
Patent; ZHUHAI YUFAN BIOTECHNOLOGIES CO., LTD; LIAO, Xuebin; (208 pag.)WO2019/206049; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics