62071-40-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62071-40-3,4-(Tetrahydropyran-4-yl)phenylamine,as a common compound, the synthetic route is as follows.
To a solution of 2,4-dichloro-i,3,5-triazine (0.93 g, 6.2 mmol) in N,Ndimethylformamide (DMF, 10 mE) at 0 C. were added sequentially N,N-diisopropylethylamine (DIEA, 1.1 mE, 6.5 mmol) and a solution of 4-(oxan-4-yl)aniline (CombiBlocks, 1.0 g, 5.6 mmol) in DMF (5 mE). The mixture was stirred at 0 C. for 30 minutes and then allowed to warm to room temperature overnight. The mixture was diluted with first with toluene and half-saturated aqueous sodium hydrogen carbonate solution and then with ethyl acetate and water. The mixture was filtered through a pad of Celite diatomaceous earth. The aqueous phase was extracted thrice with ethyl acetate. The combined extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel) to provide 4-chloro-N-(4-(tetrahydro- 2H-pyran-4-yl)phenyl)-i ,3,5-triazin-2-amine.11026] ECMS-ESI (mlz): [M+H] calcd for C,4H,5C1N40: 291.1. found: 291.2
The synthetic route of 62071-40-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics