125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The lactone (V) ( 100.0 g, 0.185 mol) was dissolved in THF (500 ml) and reacted with the suspension of calcium hydroxide ( 18.68 g, 0.185 mol) in water ( 100 ml) and stirred at 45 to 5O0C. After the reaction was(2 hrs), the mixture was poured into water (1.0 It), extracted twice with dichloromethane (3.0 It and 1.0 It each), the combined organic layer was optionally washed with water( 250 ml and concentrated to approx 700 ml at 40 to 420C. The concentrated layer was fine filtered through Whatman paper, cooled to 10 to 150C and diisopropyl ether (3.0 It) was then added to the mixture keeping the temperature below 150C. After stirring for 15 min, the precipitated solid was filtered, washed with cold diisopropyl ether and dried at 55 to 600C under vacuum for 24 hrs. Yield: 101.8 g (95.1 %); Purity (HPLC): 99.55 %, Assay (HPLC): 99.21 %: Calcium content: 3.33%; Moisture content (by K. F): 1.81 %;Residual solvents: Methanol < 0.05 %, THF < 0.05 %, Dichloromethane < 0.02 %, Diisopropyl ether < 0.01 %. 125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.
Reference£º
Patent; MOREPEN LABORATORIES LIMITED; WO2006/48893; (2006); A2;,
Tetrahydropyran – Wikipedia
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