65412-03-5, 4-(2-Aminoethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
65412-03-5, Place 5- (4-FORMYLPHENOXY) THIOPHENE-2-CARBOXAMIDE (Example 10, Part C) (0.235 g, 0.948 mmol), 2- (TETRAHYDROPYRAN-4-YL) ETHYLAMINE (0.122 g, 0.996 mmol) and 3A molecular sieves in a vial. Add methanol (4.7 mL), cap and stir overnight. Add NaBH4 (0.0359 g, 0.948 mmol) and stir until the gasses stop evolving. Load the reaction mixture directly onto a 25 g ISCO pre-load column. Dry the column in a vacuum oven at room temperature. Purify by eluting through a 40 g ISCOO column with 5% to 30% (2.0 M NH3 in methanol) in ethyl acetate over 45 minutes to give the title compound : TOF MS ES+ 361.2 (M+H) +, HRMS calcd for CL9H25N203S 361.1586 (M+H) +, found 361.1604, time 0.36 min; HPLC [YMC-Pro pack C-18 (150 x 4.6 mm, S-5 microm), 0.05% TFA/acetonitrile in 0.05% TFA/water at 1.0 mL/min, 10-20% over 5 min, 20-95% over 18], TR = 9. 4 min, 100% purity
The synthetic route of 65412-03-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/80996; (2004); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics