With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
Step 1: Preparation of ethyl 6-ethy 1-10-methoxy-2-oxo-9-(tetrahy dropy ran-4- ylmethoxy)-6,7-dihydrobenzo [a] quinolizine-3-carboxylate To a solution of ethyl 6-ethyl-9-hydroxy-10-methoxy-2-oxo-6,7- dihydrobenzo[a]quinolizine-3-carboxylate ( 100 mg, 0.29 mmol ) in DMF was added 4- (iodomethyi)tetrahydropyran ( 196.7 mg, 0.87 mmol ) and K >C() ; (80 mg, 0.58 mmol ). The mixture was stirred for 2 hours at 80 C, and then cooled to room temperature and filtered. The filtrate was concentrated in vacuo to give crude ethyl 6-ethyl- 10-methoxy-2-oxo-9- (tetrahydropyran-4-ylmethoxy)-6,7-dihydrobenzo[a]quinolizine-3-carboxylate which was used for the next step without further purification., 101691-94-5
101691-94-5 4-(Iodomethyl)tetrahydro-2H-pyran 2795507, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xingchun; JAVANBAKHT, Hassan; JIANG, Min; LIANG, Chungen; WANG, Jianping; WANG, Yongguang; WANG, Zhanguo; WEIKERT, Robert James; YANG, Song; ZHOU, Chengang; WO2015/113990; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics