New learning discoveries about 4295-99-2

As the paragraph descriping shows that 4295-99-2 is playing an increasingly important role.

4295-99-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.

To a stirred solution of 41 tetrahydro-2H-pyran-4-carbonitrile (100 g, 0.9 mol) in 15 ethanol (500 mL) and 18 water (500 mL) at rt, was added 44 hydroxylamine hydrochloride (144 g, 2.1 mol) followed by 105 K2CO3 (136.7 g, 1.0 mol) and the mixture was heated to 70 C. for 16 h. The mixture was cooled to rt and the solvent was removed by evaporation under reduced pressure. The residue was dissolved in 10% 183 MeOH in 68 DCM and filtered. The solvent was removed by evaporation under reduced pressure to afford the 45 title compound (91 g, 70%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) delta 1.56-1.63 (m, 4H), 2.23 (m, 1H), 3.24-3.32 (m, 2H), 3.81-3.97 (m, 2H), 5.40 (br s, 2H), 8.82 (s, 1H). [M+H]=145.3.

As the paragraph descriping shows that 4295-99-2 is playing an increasingly important role.

Reference£º
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 1197-66-6

1197-66-6, The synthetic route of 1197-66-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1197-66-6,2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one,as a common compound, the synthetic route is as follows.

Step 2. 2,2,6,6-tetramethyltetrahydro-2H-pyran-4-carbonitrile To a stirred solution of 2,2,6,6-tetramethyldihydro-2H-pyran-4(3H)-one (30 g, 0.192 mol) in dimethoxyethane (400 mL) was added tosylmethyl isocyanide (48.7 g, 0.249 eq) followed by the addition of tert-butyl alcohol (24.1 g, 0.326) at room temperature. The reaction mixture was cooled to 0 C. followed by portion-wise addition of potassium tert-butoxide (53.8 g, 0.48 mol). It was stirred at room temperature for 12 h. The reaction mixture was filtered after dilution with diethyl ether at 0 C. and the residue was further washed with diethyl ether. The resultant filtrate was concentrated to provide the title compound as a yellow semi-solid (22 g, 68%)

1197-66-6, The synthetic route of 1197-66-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Janssen Pharmaceutica NV; Ahmad, Ishtiyaque; Bakthavatchalam, Rajagopal; Battula, Sivaramakrishna; Gijsen, Henricus Jacobus, Maria; Wall, Mark; US2015/51225; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 14774-37-9

As the paragraph descriping shows that 14774-37-9 is playing an increasingly important role.

14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14774-37-9, EXAMPLE 77B 4-Tetrahydropyran carboxaldehyde To a solution of 116 mg (1.00 mmol) of 4-(hydroxymethyl)tetrahydropyran from Example 77A in 2 mL of CH2Cl2 was added 424 mg (1.0 mmol) of the Dess-Martin periodinane. The mixture was stirred at ambient temperature for 1 h, then filtered through diatomaceous earth. The filter cake was washed with about 3 mL of CH2Cl2, then the tilted aldehyde solution was used directly in the next step.

As the paragraph descriping shows that 14774-37-9 is playing an increasingly important role.

Reference£º
Patent; Kosogof, Christi; Liu, Bo; Liu, Gang; Liu, Mei; Nelson, Lissa T.J.; Serby, Michael D.; Sham, Hing L.; Szczepankiewicz, Bruce G.; Xin, Zhili; Zhao, Hongyu; US2005/70712; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 4295-99-2

4295-99-2 4-Cyanotetrahydro-4H-pyran 11815837, aTetrahydropyrans compound, is more and more widely used in various fields.

4295-99-2, 4-Cyanotetrahydro-4H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4295-99-2

A solution of tetrahydro-2H-pyran-4-carbonitrile (3.80 g, 34.2 mmol) in tetrahydrofuran (10 ml) was added dropwise over 5 min to a cold (-78 C.) solution of lithium diisopropylamine (37.5 mmol) in tetrahydrofuran (50 ml). After 30 min, a solution of 2-chloroethyl chloromethyl ether (5.00 g, 38.7 mmol) in tetrahydrofuran (10 ml) was added dropwise over 5 min and the mixture stirred for 30 min. The cooling bath was then removed and the solution was allowed to warm up to 25 C. then stirred for 1.5 h. The reaction mixture was quenched with saturated ammonium chloride and extracted with ethyl acetate. The organic fraction was dried over anhydrous magnesium sulfate and concentrated. Filtration of the residue on silica gel (elution toluene-ethyl acetate 8:2) followed by distillation in vacuo gave 6.33 g (91% yield) of the title nitrile as a clear oil: bp 90-100 C./0.2 torr (bulb to bulb distillation, air bath temperature). 1HNMR 400 MHz (CDCl3) delta (ppm): 1.74 (2H, m, CH2), 1.92 (2H, m, CH2), 3.58 (2H, s, CH2), 3.67 (2H, t, J=5.6 Hz, CH2), 3.74 (2H, dt, J=2.3 Hz and J=12.4 Hz, CH2), 3.83 (2H, t, J=5.6 Hz, CH2), 4.0 (2H, m, OCH2).

4295-99-2 4-Cyanotetrahydro-4H-pyran 11815837, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US2007/111984; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 101691-94-5

101691-94-5, As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

101691-94-5, 4-(Iodomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 6: Triphenyl(tetrahydropyran4-ylmethyl)phosphonium iodide; A mixture of Preparation 5 (350g, 1.55M) and triphenylphosphine (406g, 1.55M) in acetonitrile (1.6L) was heated under reflux. After 27h the mixture was cooled and filtered, washed with diethyl ether and dried in air to provide a white solid (504g). Filtrate and washings were returned to reflux and concentrated to 750mL, reflux was maintained for 16h before cooling and dilution with diethyl ether (ca 1.2L). A precipitate formed which was stirred for 30min before being filtered, washed with diethyl ether (2 x 300mL) and dried in air to yield a further crop (lOOg). Overall yield of the title compound (604 g, 80%). RT = 2.7min;m/z(ES*) = 361.2.

101691-94-5, As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

Reference£º
Patent; PROSIDION LIMITED; WO2006/16174; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 185815-59-2

185815-59-2, The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 2 Synthesis of 3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (IV; R1=isopropyl)A 100 ml three-necked round-bottom flask, under nitrogen atmosphere, is added with 98% hydrazine hydrate (19.5 g, 0.382 mols), sodium hydroxide (12.4 g, 0.309 mol) in water (150 ml) and the solution is cooled to a temperature of -5 C. 3-Isobutyl-glutaric anhydride (183.0 g, 1.075 mol) is dropped therein in about 1-2 h, keeping the temperature below 0-5 C. and the mixture is reacted for about 1 h. 35-37% Hydrochloric acid (450 ml) and toluene (400 ml) are added. Keeping a temperature of -5 C., a solution of sodium nitrite (160.0 g, 2.026 mol) in water (320 ml) is added dropwise, keeping the temperature below 10-15 C. After completion of the addition, the mixture is reacted for 15-20 minutes, afterwards the phases are separated and the aqueous phase is extracted with toluene (250 ml). The cooled combined organic phases are dropped into isopropanol (800 ml) under reflux in about 1 hour. The mixture is refluxed for about 30 minutes and the solution is concentrated to small volume. The resulting oil is taken up into hexane (500 ml) and left under strong stirring for 2-3 hours, the solid is filtered and dried at 50 C. for 16-18 hours. 205 g of a white solid are obtained, in a 78% yield.1H-NMR (300 MHz, D2O, 28 C.): delta 7.00 (broad, 1H exchange with D2O); 4.70 (m, 1H); 3.00 (m, 1H); 2.80 (m, 1H); 2.10 (m, 2H); 1.95 (m, 1H); 1.60 (m, 1H); 1.20-1.00 (m, 8H); 0.80 (d, 6H).

185815-59-2, The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dipharma Francis S.r.l.; US2009/143615; (2009); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 1194-16-7

1194-16-7, As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.

1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,2-dimethyl tetrehydropyran-4-one (5.0 g, 39.0 mmol) and ethyl diazoacetate (7.1 g, 62.4 mmol) in tetrahydrofuran (100 mL) was added lithium diisopropylamide (2 M in tetrahydrofuran, 35.1 mL, 70.2 mmol) at -78 C under nitrogen. After addition, the reaction mixture was stirred at -78 C for 1H and then quenched by addition of saturated aqueous ammonium chloride (60 mL). The mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated to dryness in vacuo. The residue was purified by column chromatography (silica gel, 100-200 mesh, 0 to 20% ethyl acetate in petroleum ether) to afford ethyl 2-diazo-2-(4-hydroxy-2,2-dimethyl-tetrahydropyran-4-yl)acetate (6.0 g, 63.5% yield) as a yellow oil use as is in the next step.

1194-16-7, As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.

Reference£º
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; PATEL, Snahel; HAMILTON, Gregory; STIVALA, Craig; CHEN, Huifen; ZHAO, Guiling; (1236 pag.)WO2017/4500; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 127956-11-0

127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of intermediate 4 (2 g, 7.2 mmol) in ethanol (100 mL) methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (2.4 g, 15 mmol, 2.1 eq.) and acetic acid (4.1 mL, 10 eq.) were added. The solution was stirred for 4 hours at reflux. The solution was then concentrated in vacuo and triturated in diisopropyl ether. The solid was filtered off and dried into the oven to give intermediate 48 (1.95 g, 72 %) as a white powder.LCMS mlz = 375 (M+H)1H NMR (400 MHz, DMSO-d6) oe ppm 1.30 – 1.38 (m, 2 H) 1.42 (s, 9 H) 1.48 – 1.63 (m, 2 H)1.64 – 1.77 (m, 1 H) 2.31 (d, J=13.64 Hz, 1 H) 2.69 (s, 2 H) 2.72 – 2.85 (m, 1 H) 3.79 – 3.96(m, 3 H) 4.44 (s, 2 H) 5.31 (br. s, 1 H) 5.77 (s, 1 H) 12.20 (s, 1 H), 127956-11-0

127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; (68 pag.)WO2016/91791; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 14774-37-9

The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.

14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 86: Tetrahvdro-2H-pyran-4-ylmethyl methanesulfonateTo tetrahydro-2H-pyran-4-ylmethanol (6.2g) in dry dichloromethane (226.3 ml) at O0C and under nitrogen, was added triethylamine (18.1 ml), followed by mesyl chloride (5.4 ml). The reaction was allowed to warm to room temperature and left at this temperature overnight. The reaction mixture was washed with saturated aqueous sodium bicarbonate (200 ml). The organic layer was separated, passed through a hydrophobic frit to dry and concentrated in vacuo to yield a light brown lumpy solid (10.17 g).1H NMR (DMSO): delta 4.06 (2H, d), 3.85 (2H, m), 3.35-3.25 (1 H, m), 3.17 (3H, s), 2.50 (1 H, m), 2.00-1.87 (1 H, m), 1.58 (2H, m), 1.32-1.20 (2H, m)., 14774-37-9

The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/101867; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.

A mixture of 5,7-dichloro-3- isopropylpyrazolo[l,5-a]pyrimidine (687 mg, 3.0 mmol), N-methyl-tetrahydro-2H-pyran-4- amine (414 mg, 3.6 mmol), and K2C03 (828 mg, 6.0 mmol) in 10 mL of acetonitrile was heated at reflux under N2 for 2 h., diluted with water (10 mL) and the mixture was extracted with EtOAc (15 mL X 3). The combined organic phases were dried over Na2S04, filtered and concentrated. The residue was purified by preparative TLC on silica gel (petroleum ether/EtOAc = 3/1) to afford 5-chloro-3-isopropyl- N-methyl-N-(tetrahydro-2H-pyran-4- yl)pyrazolo[l,5-a] pyrimidin-7-amine (813 mg, 88 % yield) as yellow solid. ESI-LCMS (m/z): 309.1 [M+l]+., 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEI, Oscar, Miguel; SHAPIRO, Gideon; DUNCAN, Kenneth, W.; MITCHELL, Lorna, Helen; JIN, Lei; BABINE, Robert, E.; (200 pag.)WO2016/44650; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics