With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of intermediate 4 (2 g, 7.2 mmol) in ethanol (100 mL) methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (2.4 g, 15 mmol, 2.1 eq.) and acetic acid (4.1 mL, 10 eq.) were added. The solution was stirred for 4 hours at reflux. The solution was then concentrated in vacuo and triturated in diisopropyl ether. The solid was filtered off and dried into the oven to give intermediate 48 (1.95 g, 72 %) as a white powder.LCMS mlz = 375 (M+H)1H NMR (400 MHz, DMSO-d6) oe ppm 1.30 – 1.38 (m, 2 H) 1.42 (s, 9 H) 1.48 – 1.63 (m, 2 H)1.64 – 1.77 (m, 1 H) 2.31 (d, J=13.64 Hz, 1 H) 2.69 (s, 2 H) 2.72 – 2.85 (m, 1 H) 3.79 – 3.96(m, 3 H) 4.44 (s, 2 H) 5.31 (br. s, 1 H) 5.77 (s, 1 H) 12.20 (s, 1 H), 127956-11-0
127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; (68 pag.)WO2016/91791; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics