With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.
A magnetic stirrer of appropriate size was added to a 50 ml reaction tube, the air was replaced and protected with nitrogen, 30 ml of methylene chloride was injected, and the reaction vessel was placed in a low-temperature stirring reaction bath (Below -65 C), inject 0.75 ml of diethylaminosulfur trifluoride by injection at low temperature, stir for about 15 minutes, then slowly add 1.50 g of atorvastatin lactone in 5 ml of dichloromethane. After stirring the reaction for about 30 minutes, about 0.3 ml of triethylamine was added by syringe, and after 2 hours, the reaction was naturally warmed up overnight. After the reaction was monitored by TLC, the filtrate was filtered and the filtrate was dried over anhydrous sodium sulfate. The residue was spin-dried and separated by column chromatography (PE / EA gradient elution) to obtain 0.76 g of atorvastatin fluoride product (001).
125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.
Reference£º
Patent; Shanghai Applied Technology College; Shanghai Huali Bio-pharmaceutical Co., Ltd.; Wang Zhonghua; Wu Fanhong; Li Bing; Yu Xiaodong; Lv Qianqian; Wu Chuang; Su Feifei; Wu Fulong; (23 pag.)CN105085497; (2017); B;,
Tetrahydropyran – Wikipedia
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