Downstream synthetic route of 1172623-99-2

As the paragraph descriping shows that 1172623-99-2 is playing an increasingly important role.

1172623-99-2, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1H (11.53 g, 35.03 mmol) was dissolved in dichloromethane (130 mL)Cooling to 0 ,The Dayton Martin oxidant (29.72 g, 70.06 mmol) was added portionwise to the reaction solution,Naturally rose to room temperature for 4 hours.Cooling to 0 ,The saturated sodium bicarbonate solution (60 mL) was added dropwise to the reaction solution,Stir for 20 minutes,filter,The filtrate was allowed to stand,The aqueous phase was extracted with methyl tert-butyl ether (60 mL x 3)Combined organic phase,The organic phase was washed with saturated sodium bicarbonate solution (30 mL x 2)Dried over anhydrous sodium sulfate,Filter concentrate,The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 10: 1-4: 1)To give white crystalline powder intermediate 1 (10.85 g, yield 94.7%)., 1172623-99-2

As the paragraph descriping shows that 1172623-99-2 is playing an increasingly important role.

Reference£º
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Chen Qingping; Wang Chengtao; (36 pag.)CN106632349; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics