Simple exploration of 61363-56-2

61363-56-2 2H-Pyran-3,5(4H,6H)-dione 325287, aTetrahydropyrans compound, is more and more widely used in various fields.

61363-56-2, 2H-Pyran-3,5(4H,6H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61363-56-2

General procedure: Tetrahydrobenzofurans and Annulated Dihydropyrans; General Procedure A mixture of 1,3-diketones 1,4, or 6 (0.25 mmol), nitroalkene 2 (0.275mmol, 1.1 equiv), catalyst A (0.5 mol%), and Ag2O (1 mol%) in CH2Cl2(2.5 mL, 0.1 M) was stirred at r.t. until the intermediate Michael ad-duct was completely converted as indicated by TLC. The crude prod-uct was directly subjected to flash chromatography on silica (n-pen-tane/Et2O or n-pentane/CH2Cl2) to afford the corresponding product3, 5, or 7.

61363-56-2 2H-Pyran-3,5(4H,6H)-dione 325287, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Kaya, U?ur; Chauhan, Pankaj; Deckers, Kristina; Puttreddy, Rakesh; Rissanen, Kari; Raabe, Gerhard; Enders, Dieter; Synthesis; vol. 48; 19; (2016); p. 3207 – 3216;,
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Brief introduction of 137052-08-5

As the paragraph descriping shows that 137052-08-5 is playing an increasingly important role.

137052-08-5, 1-(Tetrahydro-2H-pyran-4-yl)ethanone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 16. Synthesis of 3-fluoro-2-(5-oxo-4-(3-(tetrahydro-2H-pyran-4-yl)-lH- razol- l-yl)-6,7-dihydro-5H-pyrrolo [3,4-b] pyridin-2-yl)benzonitrile, I- 16 16.4 1-16 Synthesis of compound 16.2. Solution of 16.1 (0.5g, 3.9mmol, leq) in DMF-DMA (5 niL) was heated to 100 C for 16h. Upon completion of the reaction was reaction, solvents were removed under reduced pressure to get crude 16.2 (0.45g, 62.95%), MS(ES): m/z 184.12 [M+H]+. The crude product was used in to next step without further purification., 137052-08-5

As the paragraph descriping shows that 137052-08-5 is playing an increasingly important role.

Reference£º
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; MONDAL, Sayan; (342 pag.)WO2017/40757; (2017); A1;,
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Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.

To a solution of N-methyltetrahydro-2H-pyran-4-amine (172.5 mg, 1.5 mmol) in CH3CN (5 mL) was added K2CO3 (207 mg, 1.5 mmol) and 2-bromo-5-nitropyridine (203 mg, 1 mmol). The reaction was stirred at 80 C. for 16 hours. TLC and LC-Ms showed the reaction had completed and the reaction was poured into water, extracted with EA, washed with water and brine, dried and concentrated to give a yellow solid. MS (m/z): 238 (M+H)+, 220641-87-2

220641-87-2 N-Methyltetrahydro-2H-pyran-4-amine 6991950, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo; US2014/121200; (2014); A1;,
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Some tips on 1228779-96-1

1228779-96-1, The synthetic route of 1228779-96-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

Compound 13 (0.10 g, 0.18 mmol), Compound 3 (0.055 g, 0.18 mmol),1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC, 0.052 g, 0.27 mmol) and 4-dimethylaminopyridine (DMAP, 0.044 mg, 0.36 mmol) were added to It was stirred at room temperature for 10 h in dichloromethane (20 ml). The reaction was quenched with water (10 mL). Dry over anhydrous sodium sulfate, remove the solvent, The concentrate was subjected to column separation (eluent: ethyl acetate/methanol (v/v) = 30:1), Obtained 80 mg of a yellow solid, The yield was 53%.

1228779-96-1, The synthetic route of 1228779-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Liu Zhiqiang; (35 pag.)CN108658983; (2018); A;,
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Analyzing the synthesis route of 873397-34-3

The synthetic route of 873397-34-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873397-34-3,Tetrahydro-2H-pyran-3-carboxylic acid,as a common compound, the synthetic route is as follows.

873397-34-3, To a solution of tetrahydro-2H-pyran-3-carboxylic acid (44.0 mg, 0.335 mmol) in DCM (10 mL) was added HOBt (68.0 mg, 0.502 mmol), EDCI (96.0 mg, 0.502 mmo and TEA (0.28 ml, 2 mmol). After stirring at room temperature, Compound 70C (300 mg, 0.335 mmol) was added and the mixture was stirred at room temperature for 2 h. The mixture was concentrated to give a residue which was purified by prep-HPLC (Waters 2767/Qda, Column: Waters Xbridge 19* 150mm lOum, Mobile Phase A: H20 (0.1percentNH4OH), B: ACN) to yield Compound 92 (45 mg, 24.3percent yield) as a white solid. NMR CD3OD (400 MHz) delta 8.30 (s, 1H), 7.65 (s, 1H), 4.52-4.49 (m, 1H), 4.08-4.00 (m, 5H), 3.93-3.89 (m, 2H), 3.86-3.80 (m, 2H), 3.53-3.39 (m, 2H), 3.16-3.10 (m, 1H), 2.97-2.92 (m, 1H), 2.66-2.60 (m, 4H), 2.51-2.48 (m, 2H), 2.29-2.22 (m, 3H), 1.94-1.76 (m, 5H), 1.82-1.69 (m, 4H), 1.15-1.03 (m, 2H).

The synthetic route of 873397-34-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; ANGIBAUD, Patrick, Rene; PANDE, Vineet; HERKERT, Barbara; KROSKY, Daniel, Jason; QUEROLLE, Olivier, Alexis, Georges; PATRICK, Aaron Nathaniel; (161 pag.)WO2018/50684; (2018); A1;,
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Some tips on 53911-68-5

53911-68-5 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione 104639, aTetrahydropyrans compound, is more and more widely used in various fields.

53911-68-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53911-68-5,4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

General procedure: An alcohol (5 mmol) was added dropwise at room temperature under nitrogen to astirred solution of an anhydride 8 (0.5 mmol) and 7i (36.1 mg, 0.05 mmol) in MTBE(20 mL). The reaction was monitored by using thin-layer chromatography. Onceanhydride consumption was complete, the solvent was evaporated under reducedpressure and the residue was dissolved in CH2Cl2 (10 mL). The solution was washedwith saturated Na2CO3 (2 ¡Á 5 mL) and the combined aqueous phase were acidifiedwith excess 2 N HCl, followed by extraction with EtOAc (3 ¡Á 10 mL). The combinedorganic phases were dried over Na2SO4 and concentrated to afford the correspondingmonoester, without further purification by flash chromatography

53911-68-5 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione 104639, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Xu, Lingjun; Han, Shuwen; Yan, Linjie; Wang, Haifeng; Peng, Haihui; Chen, Fener; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 309 – 317;,
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Analyzing the synthesis route of 130290-79-8

As the paragraph descriping shows that 130290-79-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130290-79-8,(Tetrahydro-2H-pyran-4-yl)methanamine,as a common compound, the synthetic route is as follows.,130290-79-8

A mixture of 4-fluoro-3-nitrobenzenesulfonamide (2.18 g), l-(tetrahydropyran-4- yl)methylamine (1.14 g), and triethylamine (1 g) in tetrahydrofuran (30 mL) were stirred overnight, neutralized with concentrated HC1 and concentrated. The residue was suspended in ethyl acetate and the precipitates were collected, washed with water and dried to provide the title compound.

As the paragraph descriping shows that 130290-79-8 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; CATRON, Nathaniel D.; CHEN, Shuang; GONG, Yuchuan; ZHANG, Geoff G.; WO2012/71336; (2012); A1;,
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Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 125995-03-1

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various fields.

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the residue 95 kg of methanol and NaOH solution ( 2 eqv. 3.28 kg NaOH was dissolved in 26.7 kg of water) were added. The mixture was stirred at 35-45 0C for 30-40 minutes. TLC analysis showed that all the starting materials were converted into the sodium salt of Atorvastatin., 125995-03-1

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ULKAR KIMYA SAN. VE TIC. A.S.; WO2009/82362; (2009); A1;,
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Analyzing the synthesis route of 31608-22-7

The synthetic route of 31608-22-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31608-22-7,2-(4-Bromobutoxy)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

The title compound, a grignard reagent, was prepared from 2- (5-BROMO-BUTYLOXY)- TETRAHYDRO-PYRAN by reaction with magnesium., 31608-22-7

The synthetic route of 31608-22-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN; WO2004/98582; (2004); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 5631-96-9

5631-96-9 2-(2-Chloroethoxy)tetrahydro-2H-pyran 254951, aTetrahydropyrans compound, is more and more widely used in various fields.

5631-96-9, 2-(2-Chloroethoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 3 (2.64 g, 4.02 mmol), commercially available 2-(2-chloroethoxy) tetrahydro-2H-pyran (4) (0.79 g, 4.82 mmol), K2CO3 (1.11 g, 8.04 mmol) and KI (0.13 g, 0.80 mmol) in N,N-dimethylformamide (DMF) (40 mL) under argon was stirred overnight at 90C. After cooling to room temperature, themixture was diluted with CHCl3 (200 mL) and H2O (200 mL). The aqueous phase was extracted with CHCl3 (100 mL, twice), and the combined organic phases were washed with brine (50 mL), dried over MgSO4 and evaporated to give crude 5. Purification of the crude sample by column chromatography over silica gel (hexane/EtOAc) gave pure 5 (1.22 g, 39% yield)., 5631-96-9

5631-96-9 2-(2-Chloroethoxy)tetrahydro-2H-pyran 254951, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Hattori, Yoshiyuki; Hara, Eriko; Shingu, Yumiko; Minamiguchi, Daiki; Nakamura, Ayako; Arai, Shohei; Ohno, Hiroaki; Kawano, Kumi; Fujii, Nobutaka; Yonemochi, Etsuo; Biological and Pharmaceutical Bulletin; vol. 38; 1; (2015); p. 30 – 38;,
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Tetrahydropyran – an overview | ScienceDirect Topics