5631-96-9, 2-(2-Chloroethoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 3 (2.64 g, 4.02 mmol), commercially available 2-(2-chloroethoxy) tetrahydro-2H-pyran (4) (0.79 g, 4.82 mmol), K2CO3 (1.11 g, 8.04 mmol) and KI (0.13 g, 0.80 mmol) in N,N-dimethylformamide (DMF) (40 mL) under argon was stirred overnight at 90C. After cooling to room temperature, themixture was diluted with CHCl3 (200 mL) and H2O (200 mL). The aqueous phase was extracted with CHCl3 (100 mL, twice), and the combined organic phases were washed with brine (50 mL), dried over MgSO4 and evaporated to give crude 5. Purification of the crude sample by column chromatography over silica gel (hexane/EtOAc) gave pure 5 (1.22 g, 39% yield)., 5631-96-9
5631-96-9 2-(2-Chloroethoxy)tetrahydro-2H-pyran 254951, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Article; Hattori, Yoshiyuki; Hara, Eriko; Shingu, Yumiko; Minamiguchi, Daiki; Nakamura, Ayako; Arai, Shohei; Ohno, Hiroaki; Kawano, Kumi; Fujii, Nobutaka; Yonemochi, Etsuo; Biological and Pharmaceutical Bulletin; vol. 38; 1; (2015); p. 30 – 38;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics