1768-64-5, 4-Chlorotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 4 (0.054g, 0.20mmol), K2CO3 (0.11g, 0.8mmol), DMF (2.0mL), and 4-chlorotetrahydro-2H-pyran (0.072g, 0.60mmol) in a 10mL microwave tube was heated under microwave irradiation at 200C for 30min. After cooling to room temperature, (4-(N-methylsulfamoyl)phenyl)boronic acid (0.065g, 0.30mmol), Pd(PPh3)4 (0.023g, 0.020mmol), and H2O (1.0mL) were added sequentially. The resulting mixture was stirred at room temperature for 1.0min and then heated under microwave irradiation at 150C for 15min. After cooling to room temperature, the mixture was quenched with H2O and extracted with EtOAc (3¡Á). The combined organic layers were dried (Na2SO4) and concentrated. The combined organic layer was dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by an ISCO silica gel column to provide the title compound 14 as a white solid (0.052g, 61% over 2 steps)., 1768-64-5
As the paragraph descriping shows that 1768-64-5 is playing an increasingly important role.
Reference£º
Article; Liu, Jing; Zhang, Weihe; Stashko, Michael A.; DeRyckere, Deborah; Cummings, Christopher T.; Hunter, Debra; Yang, Chao; Jayakody, Chatura N.; Cheng, Nancy; Simpson, Catherine; Norris-Drouin, Jacqueline; Sather, Susan; Kireev, Dmitri; Janzen, William P.; Earp, H. Shelton; Graham, Douglas K.; Frye, Stephen V.; Wang, Xiaodong; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 83 – 93;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics