7525-64-6, 4-Methyltetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7525-64-6
Example’7-2 2-Chloro-N- (4-methyltetrahydro-2H-pyran-4-yl) acetamide To a solution of 4-methyltetrahydro-2H-pyran-4-ol obtained in Example 7-1 in chloroacetonitrile (0. 65mL), was added a mixture of acetic acid and conc. sulfuric acid (1/1, 1. 6mL) dropwise with cooling on an ice bath. The reaction mixture was warmed to room temperature and stirred for 3hrs. The reaction mixture was quenched by adding 3N NaOH. The resulting solution was extracted with ethyl acetate. The combined organic layer was washed with saturated aqueous NaCl, dried over MgS04, and concentrated in vacuo. The residue was purified with silica gel chromatography (hexane/ethyl acetate = 1/2) to give the target compound as a white powder (630 mg). 1H-NMR (300MHz, CDC13) : 6 1.46 (3H, s), 1.83-1. 67 (2H, m), 2.14-2. 00 (2H, m), 3.67-3. 55 (2H, m), 3.81-3. 67 (2H, m), 4.00 (2H, s), 4.03 (1H, br-s). Mass (ES+) m/z : 192.16 (M+1).
The synthetic route of 7525-64-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; WO2005/42533; (2005); A2;,
Tetrahydropyran – Wikipedia
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