4295-99-2, 4-Cyanotetrahydro-4H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4295-99-2
To a solution of tetrahydro-2H-pyran-4-carbonitrile (10 g, 90 mmol) in dry THF (100 mL) at 0 C. was added dropwise 1.0 M NaHDMS in THF (108 mL, 108 mmol). The mixture was stirred for 1.5 h at 0 C., then treated with CH3I (38 g, 270 mmol) slowly. The mixture was stirred at RT for 16 h, then cooled to 0 C. and treated with 1 M aq. HCl (150 mL) and extracted with EtOAc (300 mL). The organic layer was washed with sat. aq. NaCl (80 mL*3), dried over MgSO4, filtered and concentrated under reduced pressure to give the title compound as a pale yellow liquid (10 g, 87%). 1H NMR (CDCl3) delta 3.98-3.92 (m, 2H), 3.74-3.65 (m, 2H), 1.89-1.82 (m, 2H), 1.66-1.56 (m, 2H), 1.42 (s, 3H).
As the paragraph descriping shows that 4295-99-2 is playing an increasingly important role.
Reference£º
Patent; Board of Regents, The University of Texas System; LE, Kang; SOTH, Michael J.; LIU, Gang; JONES, Philip; CROSS, Jason Bryant; MCAFOOS, Timothy Joseph; CARROLL, Christopher L.; LEWIS, Richard T.; (199 pag.)US2019/308978; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics