Simple exploration of 951127-25-6

951127-25-6, 951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67b (1.16 g, 2.11 mmol) and Intermediate 1 (830 mg, 2.53 mmol) were dissolved in N, N-dimethylacetamide (10 mL)The mixture was stirred at room temperature for 1 hour, Sodium tris(acetoxy)borohydride (2.71 g, 12.77 mmol) was added and stirred at room temperature for 2 hours. The reaction solution was added to saturated sodium bicarbonate solution (100 mL) and stirred for 0.5 hour. The filter cake was washed with water (20 mL x 3), dried and chromatographed on silica gel column chromatography (dichloromethane / methanol (v / V = 50: 1),To give a yellow solid tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(1,5-dimethyl-1H-pyrazol-3-yl)-1-ethylpyrrolo[3,4-d]imidazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-yl)carbamate(67c) (800 mg, yield 70%).

951127-25-6, 951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Analyzing the synthesis route of 23462-75-1

23462-75-1, The synthetic route of 23462-75-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23462-75-1,Dihydro-2H-pyran-3(4H)-one,as a common compound, the synthetic route is as follows.

Tetrahydrofuran (50 mL) was added to a round bottom flask and placed under N2. trimethyl(trifluoromethyl)silane (1.033 mL, 6.99 mmol) was then added and stirred under N2and then cooled to 0 C. Dihydro-2H-pyran-3(4H)-one (500 mg, 4.99 mmol) was then added via syringe and stirred for 5 minutes at 0 C. to ensure complete mixing. TBAF (0.050 mL, 0.050 mmol) was added dropwise slowly via syringe. The reaction was then allowed to warm up to RT for 30 min. The reaction was then cooled back down to 0 C. and added 1M HCl (50 mL) and then stirred at RT for overnight. The reaction was diluted with water and EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered and evaporated to give the crude product 3-(trifluoromethyl)tetrahydro-2H-pyran-3-ol (400 mg, 47.1% yield) as an oil.1H NMR (400 MHz, CHLOROFORM-d) delta 4.01-3.93 (m, 1H), 3.82 (dd, J=11.8, 2.5 Hz, 1H), 3.60 (d, J=12.0 Hz, 1H), 3.41 (td, J=11.8, 2.5 Hz, 1H), 2.10-2.08 (m, 2H), 1.97-1.90 (m, 1H), 1.82 (dd, J=12.9, 4.4 Hz, 1H), 1.65-1.55 (m, 1H).

23462-75-1, The synthetic route of 23462-75-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P.V.K. Suresh; Scola, Paul Michael; (403 pag.)US9527885; (2016); B2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 1240390-36-6

The synthetic route of 1240390-36-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1240390-36-6,tert-Butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

Step 5 tert-Butyl (3R,4R)-4-(6-carbamoyl-5-(5-isopropyl-6-methoxypyridin-2-ylamino)pyridazin-3-ylamino)tetrahydro-2H-pyran-3-ylcarbamate To a solution of 6-chloro-4-(5-isopropyl-6-methoxypyridin-2-ylamino)pyridazine-3-carboxamide (250 mg, 777 mumol) in NMP (2.6 mL) was added tert-butyl (3R,4R)-4-aminotetrahydro-2H-pyran-3-ylcarbamate (672 mg, 2.33 mmol) in four portions approximately every 12 h and heated to 140 C. in the periods between additions. After a total of 48 h, the mixture was cooled then diluted with ethyl acetate and brine. The phases were separated then the organic phase was washed with brine (2*), concentrated in vacuo and purified by chromatography (silica, 0 to 4% of a 99.5:0.5 methanol:NH4OH solution in dichloromethane) to give tert-butyl (3R,4R)-4-(6-carbamoyl-5-(5-isopropyl-6-methoxypyridin-2-ylamino)pyridazin-3-ylamino)tetrahydro-2H-pyran-3-ylcarbamate (141 mg, 281 mumol, 36%) as light brown solid. MS (EI/CI) m/z: 502.3 [M+H]., 1240390-36-6

The synthetic route of 1240390-36-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Analyzing the synthesis route of 40191-32-0

The synthetic route of 40191-32-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40191-32-0,Tetrahydro-2H-pyran-4-carbonyl chloride,as a common compound, the synthetic route is as follows.

Step 3 To a mixture 6-(6-methoxy-5-methyl-pyridin-3-yl)-4-((S)-pyrrolidin-3-yloxy)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine (639 mg, 1 .87 mmol) in CH2CI2 (5 mL) was added the acid chloride tetrahydo-2H-pyran-4-carbonyl chloride (306 mg, 2.06 mmol) and triethylamine (0.522 mL, 3.74 mmol) at rt. The reaction mixture was stirred at rt for 10 min. The reaction mixture was concentrated under vacuum. Purification by preparative reverse phase Gilson HPLC and subsequent neutralization of the combined fractions by extraction with CH2CI2/1 N NaOH, separation of the organic phase through a phase separation tube and evaporated gave {(S)-3-[6-(6-methoxy-5-methyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy]-pyrrolidin-1-yl}-(tetrahydro-pyran-4-yl)-methanone (432 mg, 51 % yield) as a white powder. 1 H-NMR (400 MHz, DMSO-d6, 298K) delta ppm 1 .50-1.65 (m, 4H) 2.10-2.32 (m, 5H) 2.62-2.78 (m, 1 H) 2.85-2.95 (m, 2H) 3.30-3.95 (m, 13H) 4.0-4.20 (m, 2H) 5.61-5.72 (m, 1 H) 7.42 (br, 1 H) 7.68 (m, 1 H) 8.60-8.61 (m, 1 H) . LCMS: [M+H]+=454.2, Rt (1)= 1.42min, 40191-32-0

The synthetic route of 40191-32-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOeGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; WO2013/88404; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 1194-16-7

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various fields.

1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl-2-amino-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylate Following a previously reported procedure,42 a mixture of 2,2-dimethyldihydro-2H-pyran-4(3H)-one (0.30 g, 2.34 mmol, 1 eq), tert-butyl cyanoacetate (0.37 mL, 2.57 mmol, 1.1 eq), sulfur (0.083 g, 2.57 mmol, 1.1 eq), morpholine (0.30 mL, 3.51 mmol, 1.5 eq), and ethanol (7 mL) was heated at 50 C. for 16 h. The reaction mixture was then filtered, and the filter cake washed with ethyl acetate (20 mL). Purification by silica gel chromatography (0-20% EtOAc/Hex ramp over 20 min) afforded the desired product tert-butyl 2-amino-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylate as a yellow solid (0.63 g, 2.23 mmol, 95% yield). 1H NMR (400 MHz, CDCl3) delta 5.88 (s, 2H), 4.52 (apparent t, J=1.9, 2H), 2.64 (apparent t, J=1.9, 2H), 1.53 (s, 9H), 1.26 (s, 6H). 13C NMR (101 MHz, CDCl3) delta 165.22, 161.77, 130.07, 113.43, 106.94, 80.38, 70.83, 59.81, 38.72, 28.56, 26.46., 1194-16-7

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; STC.UNM; University of Kansas; Wandinger-Ness, Angela; Sklar, Larry; Agola, Jacob; Surviladze, Zurab; Aube, Jeffrey; Golden, Jennifer; Schroeder, Chad E.; Simpson, Denise S.; US8765803; (2014); B1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 1197-66-6

1197-66-6 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one 11829691, aTetrahydropyrans compound, is more and more widely used in various fields.

1197-66-6, 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,2,6,6-tetramethyldihydro-2H-pyran-4(3H)-one (prepared according to PCT Int. AppL, WO2010021680) (2.30 g, 14.72 mmol) in 14 mL of THF and 5 mL of ethano was added sodium borohydri.de (0.56 g, 14.72 mmol) and the mixture stirred at RT for 8 hrs. The mixture was diluted with 50 mL of EtOAc and washed with 50 mL of 0.2 N HC1 and 50 mL of brine. The aqueous layer was again extracted with EtOAc (3 x 50 mL) and the organic fractions combined, dried over sodium sulfate and concentrated to give 2.30 g (99%) of compound lc as a white solid that was used without further purification. NMR ( CHLOROFORM-d) delta: 4.13 fit, J – 11.4, 4.3 Hz, 1H), 1.94 (dd, J = 12.5, 4.2 Hz, 2), 1.28 f s, 6H), 1.27 – 1.22 (m, 8H)., 1197-66-6

1197-66-6 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one 11829691, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; WALL, Mark; SUBASINGHE, Nalin; SUI, Zhihua; FLORES, Christopher; WO2014/28800; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 125552-89-8

125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.

125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 8d (370mg, 2.52mmol) in anhydrous DMF (5mL) cooled to O0C, was added 60% NaH (121mg, 3.02mmol) slowly. The resulting mixture was stirred at O0C for Ih, was then added 4-(bromomethyl) -2H-3,4,5,6- tetrahydropyran (25a) (496g, 2.77mmol). The resulting mixture was then heated at 6O0C overnight. After being evaporated, the mixture was purified by column chromatography (PE:EA=10:l) to provide 25b (541mg, 87.6%).

125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XCOVERY, INC.; WO2008/88881; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 951127-25-6

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At room temperature, A solution of 1a (0.215 g, 0.62 mmol) was dissolved N,N-dimethylacetamide (4 mL) was added intermediate 1 (0.225 g, 0.69 mmol), and the mixture was stirred at room temperature for 1 hour. Cooling to 0C ,Sodium tris(acetoxy)borohydride (0.171 g, 0.806 mmol) was added to the reaction solution, Add natural to room temperature reaction for 16 hours.The reaction solution was cooled to 0 C, water (20 mL) was added in that order, and the pH was adjusted to 8 with aqueous ammonia (2 mL). The organic phase was extracted with dichloromethane (50 mL x 3), washed with saturated brine solution (50 mL x 1) Dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated and purified by column chromatography (dichloromethane / methanol (v / v) = 30: 1) to give yellow solid 1b (0.179 g, 56.1% yield)., 951127-25-6

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 23462-75-1

23462-75-1, As the paragraph descriping shows that 23462-75-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23462-75-1,Dihydro-2H-pyran-3(4H)-one,as a common compound, the synthetic route is as follows.

To a -78 C solution of 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1.5 g, 5.4 mmol) in tetrahydrofuran (50 mL) was added n-butyllithium (2.5 M, 6.4 mL, 16.1 mmol) drop-wise. After the reaction mixture had been stirred at -78 C for 2 hours, it was treated with dihydro-2H-pyran-3(4H)-one (1.61 g, 16.1 mmol), warmed to roomtemperature, and stirred for 18 hours. The reaction was quenched with water (50 mL), and the aqueous layer was extracted with ethyl acetate (3 x 30 mL); the combined organic layers were washed with saturated aqueous sodium chloride solution (100 mL), dried over sodium sulfate, filtered, and concentrated. Silica gel chromatography (Gradient: 0% to 50% ethyl acetate in petroleum ether) afforded the product as a yellowoil. Yield: 200 mg, 0.79 mmol, 15%. LCMS m/z 254.0 [M+H].

23462-75-1, As the paragraph descriping shows that 23462-75-1 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; GALATSIS, Paul; HAYWARD, Matthew Merrill; HENDERSON, Jaclyn; KORMOS, Bethany Lyn; KURUMBAIL, Ravi G; STEPAN, Antonia Friederike; VERHOEST, Patrick Robert; WAGER, Travis T.; ZHANG, Lei; WO2014/1973; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 108-55-4

108-55-4, The synthetic route of 108-55-4 has been constantly updated, and we look forward to future research findings.

108-55-4, Dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1: Preparation of 5-oxo-5-(2-oxo-4-phenyl-oxazolidin-3-yl)-pentanoic acid benzyl ester Benzyl alcohol (95.Og, 0.88mol) and sodium metal (2.01g, 0.087mol) were mixed and stirred for 30 minutes. Then, the reaction mixture was heated to 80-850C and stirred to dissolve the sodium metal. Glutaric anhydride (10Og, 0.876mol) was added and stirred for further 2 hours at 80-850C. The reaction mixture was cooled to 25-3O0C and to this dichloromethane (250ml) and demineralized water (1×25 OmI) were added. The layers were separated; organic layer was dried over sodium sulfate and concentrated at 40-450C. The reaction mixture was cooled and dichloromethane (850ml) was added. The reaction mixture was cooled to 10-150C under nitrogen atmosphere. Triethylamine (214ml, 1.535mol) was added followed by the slow addition of pivaloyl chloride (110 ml, 0.893mol). The reaction mixture was stirred at 25-3O0C for 90 minutes followed by addition of (S)-4-phenyl-2- oxazolidinone (86g, 0.527mol), N,iV-dimethyl formamide (92ml) and 4-dimethyl amino pyridine (15g, 0.123mol). The reaction mass was further refluxed for 6 hours and then cooled to 10-200C. Dilute sulphuric acid was added to the reaction mixture and stirred for 15 minutes. The layers were separated; organic layer was washed with 10% aqueous sodium bicarbonate solution (500ml) and demineralized water (500ml). The organic layer was concentrated at atmospheric pressure and finally under reduced pressure at 40-500C. Ethanol (600ml) was added to the reaction mixture and cooled to 20-300C. Title compound (1.Og) was added as seeds to the reaction mixture and stirred for 60 minutes at 20-300C. The reaction mixture was again cooled to 0-50C, stirred for 2 hours, filtered and washed with ethanol (100ml) to afford 180g of the title compound having purity 99.41% by HPLC.

108-55-4, The synthetic route of 108-55-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IND-SWIFT LABORATORIES LIMITED; WO2009/157019; (2009); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics