951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
67b (1.16 g, 2.11 mmol) and Intermediate 1 (830 mg, 2.53 mmol) were dissolved in N, N-dimethylacetamide (10 mL)The mixture was stirred at room temperature for 1 hour, Sodium tris(acetoxy)borohydride (2.71 g, 12.77 mmol) was added and stirred at room temperature for 2 hours. The reaction solution was added to saturated sodium bicarbonate solution (100 mL) and stirred for 0.5 hour. The filter cake was washed with water (20 mL x 3), dried and chromatographed on silica gel column chromatography (dichloromethane / methanol (v / V = 50: 1),To give a yellow solid tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(1,5-dimethyl-1H-pyrazol-3-yl)-1-ethylpyrrolo[3,4-d]imidazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-yl)carbamate(67c) (800 mg, yield 70%).
951127-25-6, 951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
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