951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The [(2R, 3S) -5 – oxo -2 – (2, 5 – difluorophenyl) tetrahydro – 2H – pyran -3 – yl] tert-butyl carbamate (108 mg, 0 . 499mmol) and 2 – (dimethylamino sulfonyl) – 2, 6 – dihydro-pyrrolo [3, 4 – c] pyrazole (163 mg, 0 . 499mmol) dissolved in 5 ml methanol solution, then adding boric (18 mg, 0 . 15mmol), after the reaction overnight at room temperature, the solvent is removed under reduced pressure after silica gel column chromatography (dichloromethane: methanol=50:1) to obtain white solid 180 mg, this white solid is dissolved in 5 ml dichloromethane in, then add 1 ml trifluoroacetic acid, room temperature reaction 2h after, after the removing the solvent under reduced pressure, in and after the proper amount of ammonia water, silica gel column chromatography (dichloromethane: methanol=20:1) to obtain 114 mg of white solid, yield 78%., 951127-25-6
951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Chengdu Rongke Bo Hai Technology Co., Ltd.; Li Xiuping; (19 pag.)CN106543188; (2017); A;,
Tetrahydropyran – Wikipedia
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