With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.
To a 500 mL round-bottom flask was added 2,2-dimethyloxan-4-one 329a (10 g,78.02 mmol, 1.00 equiv.) and methanol (100 mL). NaBH4 (5.9 g, 155.96 mmol, 2.00 equiv.)5 was added in several batches at 0C. The resulting mixture vas stirred at room temperaturefor 3 h, then diluted with 200 mL of EA, vvashed vvith brine (l 00 mL x 2), dried overanhydrous sodium sulfate, and concentrated under vacuum The residue vvas purified by silicagel column chromatography eluting with ethyl acetate in petroleum ether (0% tolOO%) togive 2,2-dirnethyloxan-4-ol 329b (9 g, 89%) as a light yellow oil., 1194-16-7
1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics