951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,951127-25-6
60b (1.03 g, 1.83 mmol) was dissolved in dimethylacetamide (15 mL)Intermediate 1 (0.61 g, 1.83 mmol) was added at room temperature for 30 min.The reaction system was cooled to 0 C, sodium borohydride triacetate (0.98 g, 4.46 mmol) was added, reacted for 30 minutes, The reaction was continued at room temperature for 2 hours.The reaction solution was cooled to 0 C, water (40 mL) was added in that order, and the water was adjusted to 9 with aqueous ammonia (5 mL). The solid was precipitated and washed with water (50 mL x 3). The solid was dissolved in dichloromethane and treated with dichloromethane ), The organic phase was combined, washed with saturated brine solution (50 mL x 1), dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated and the column chromatography was separated and purified (dichloromethane / methanol (v / v) = 20: 1 ),A yellow solid 60c (0.57 g, yield 58%) was obtained.
As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
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