1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2,2-Dimethyltetrahydropyran-4-one 1 (5.0 g, 32.0 mmol) was dissolved in methanol (4.7 ml) and carbon disulfide (4.7 ml, 48.8 mmol) was added in one portion. Malononitrile (2.6 g, 39.0 mmol) was added portionwise and, finally, triethylamine (1.95 ml) was added dropwise. The reaction mixture was stirred at room temperature for 48 h. An orange precipitate was formed, which was filtered (3.90 g), its 1H NMR being consistent with the desired compound 2. From the filtrates, 0.89 g more of 6-amino-3,3-dimethyl-8-thioxo-4,8-dihydro-1H,3H-thiopyrano[3,4-c]pyran-5-carbonitrile were isolated by flash chromatography, eluting first with CH2Cl2 and next with the mixture of solvents CH2Cl2:MeOH 98:2. Yield = 48%. 1H NMR (200 MHz, CDCl3) delta ppm 1.30 (s, 6 H), 2.62 (s, 2 H), 4.66 (s, 2 H), 7.91 (s, 2 H)., 1194-16-7
The synthetic route of 1194-16-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Taltavull, Joan; Serrat, Jordi; Grcia, Jordi; Gavald, Amadeu; Cordoba, Mnica; Calama, Elena; Montero, Jose Luis; Andres, Miriam; Miralpeix, Montserrat; Vilella, Dolors; Hernandez, Begona; Beleta, Jorge; Ryder, Hamish; Pags, Lluis; European Journal of Medicinal Chemistry; vol. 46; 10; (2011); p. 4946 – 4956;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics