With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28244-94-2,4-Methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-¦Â-D-glucopyranoside,as a common compound, the synthetic route is as follows.
General procedure: Oxidation condition a: thioglycoside substrate (0.40 mmol) and phenol (10 eq, 376 mg) were mixed to form a syrup state solution. H2O2 (2 eq, 82 muL, 30%) was added into the reaction solution, and the flask was heated to 60 C. The reaction solution was maintained at 60 C for 3 hours until all thioglycoside was transformed into glycosyl sulfoxide. The reaction solution was diluted with dichloromethane (20 ml), then was washed with dilute NaOH solution (5%, 10 ml) and water. The organic phase was dried with anhydrous Na2SO4. The corresponding glycosyl sulfoxide was separated by column chromatography. Oxidation condition b: thioglycoside substrate (0.40 mmol) and phenol (2 eq, 75 mg) were dissolved in AcOH (2 ml), H2O2 (2 eq, 82 muL, 30%) was added into the solution. The reaction was maintained at room temperature for 24 hours until all thioglycoside was transformed into glycosyl sulfoxide. The reaction solution was diluted with dichloromethane (20 ml), then was washed with dilute water and saturated NaHCO3 solution. The organic phase was dried with anhydrous Na2SO4. The corresponding glycosyl sulfoxide was separated by column chromatography., 28244-94-2
The synthetic route of 28244-94-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wang, Qing; Wei, Xiong; Liao, Kaijun; Li, Hui; Meng, Xiangbao; Li, Zhongjun; Tetrahedron Letters; vol. 57; 21; (2016); p. 2277 – 2279;,
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