With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693287-79-5,tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate,as a common compound, the synthetic route is as follows.,693287-79-5
Step 2: NaBH3CN (1.26g, 20mmol) was added slowly to a solution of 1c obtained above in 50% acetic acid (7OmL). The mixture was stirred for 1.5h at r.t., neutralized with 1N NaOH and extracted with DCM. The extract was washed with sat. NaHCO3, dried and evaporated to give 1d (4.3g, ca. 100%) as a white solid. TFA (23g, 0.2mol) was added to a solution of 1d in DCM (30mL). The reaction mixture was stirred at r.t. for 2h and evaporated to dryness to provide 1e (6.8g) which was used for next step directly.
As the paragraph descriping shows that 693287-79-5 is playing an increasingly important role.
Reference£º
Patent; TYROGENEX, INC.; LIANG, Congxin; LI, Zhigang; WO2010/56320; (2010); A2;,
Tetrahydropyran – Wikipedia
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