With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
Intermediate 1 (1005 mg, 3.07 mmol) was dissolved in N,N-dimethylacetamide (10 mL)Add 25b (820.50mg, 2.56mmol), add finished, at room temperature for 1 hour, ice bath to 0 C ,Sodium tris (acetoxy) borohydride (1080 mg, 5.12 mmol) was added and the mixture was stirred at 0 C for 2 hours at room temperature.(25 mL), ammonia (2.5 mL) was added to the reaction mixture, stirred for 20 minutes, filtered, the filter cake was washed with water (50 mL x 6), and the filter cake was separated by column chromatography (dichloromethane / methanol (V / v) = 50: 1) to give brown solid 25c (1.05 mg, yield 87%)., 951127-25-6
951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
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