With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38041-19-9,Tetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.
[0380] Tetrahydro-2H-pyran-4-amine (90 mg, 0.9 mmol) was added to a solution of formaldehyde (37% solution in water, 0.09I mL, 1.13 mmol) and acetic acid (0.162 mL) in ACN (0.8 mL). After stirring for 5 minutes, Na(CN)BH3 (60 mg, 1.13 mmol) was added in one portion at RT. After 1 hour, excess Cs2COa was added to the reaction until made alkaline. After stirring for 15 minutes, the reaction was filtered to remove solids and the solvent evaporated under reduced pressure. The crude product, N- methyltetrahydro-2H-pyran-4-amine, was used for the following displacement without further purification. LC/MS (m/z): 116.1 (MH+), Rt 0.34 minutes.
38041-19-9, The synthetic route of 38041-19-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; WO2007/84786; (2007); A1;,
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