With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28244-94-2,4-Methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-¦Â-D-glucopyranoside,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of tetra-acetylthioglycoside (2.5 g) in dry MeOH, a catalytic amountof NaOMe (31.33 mg) was added and stirred overnight. After completion, the reactionmixture was neutralized with AMBERLITE resin IR-120 (H+ form) and filtered. Thesolvent was evaporated and dried in high vacuum. The crude tetraol was stirred inpyridine at 0 C to which BzCl was added drop-wise followed by a catalytic amount ofDMAP. The reaction mixture was stirred overnight and concentrated in rota-evaporator.Further, the crude residue was diluted with H2O and extracted with EtOAc (3 ¡Á 20 mL).The combined organic layers were washed with 0.1 N HCl solution followed by brineand dried over anhydrous Na2SO4. Finally, the organic layer was concentrated andpurified by column chromatography (hexane:EtOAc) to obtain the title compounds in>75% yield over two steps., 28244-94-2
As the paragraph descriping shows that 28244-94-2 is playing an increasingly important role.
Reference£º
Article; Singh, Adesh Kumar; Tiwari, Varsha; Mishra, Kunj Bihari; Gupta, Surabhi; Kandasamy, Jeyakumar; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1139 – 1144;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics