With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1768-64-5,4-Chlorotetrahydropyran,as a common compound, the synthetic route is as follows.
EXAMPLE 100 Preparation of: NaCN (2.85 g, 0.058 mol) was suspended in DMSO (22 mL) and heated to 140 C. To the stirring suspension was added 4-chlorotetrahydropyran (5.0 g, 0.041 mol). The reaction mixture was stirred at 135-145 C. for 1.5 hours and then cooled to room temperature. The reaction was diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was passed through a silica gel plug eluding with hexane/ethyl acetate (1:1) to provide 4-cyanotetrahydropyran (0.65 g)., 1768-64-5
1768-64-5 4-Chlorotetrahydropyran 137202, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Eli Lilly and Company; US6436964; (2002); B1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics