With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of methyl 4-oxooxane-3-carboxylate (550 mg, 3.480 mmol, 1.00 equiv) in diethyl ether (20 ml_) at 0 C was added sodium hydride (208 mg, 5.200 mmol, 1.50 equiv, 60%) and the mixture was stirred at 15 C for 1 h. T riflic anhydride (1.50 g, 5.320 mmol, 1.53 equiv) was then added and resulting mixture was stirred overnight at 15 C. The reaction was quenched by the addition of water and the resulting solution was extracted with ethyl acetate (3 x 10 ml_) and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum to yield methyl 4- [(trifluoromethane)sulfonyloxy]-5,6-dihydro-2H-pyran-3-carboxylate as yellow oil.
127956-11-0, The synthetic route of 127956-11-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; LANTER, James C.; WALL, Mark; SUI, Zhihua; (0 pag.)WO2019/171278; (2019); A1;,
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