25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound (64 mg, 0.2 mmol) obtained in step 217 1 was dissolved in 6 dichloromethane (2.0 mL), 8 triethylamine (82 muL, 0.60 mmol) and 111 di-tert-butyl dicarbonate (48 mg, 0.22 mmol) were added, and the mixture was stirred at room temperature for two nights. To the reaction mixture was added 72 water, and the mixture was extracted with dichloromethane. The organic layer was washed with saturated brine, and dried over sodium sulfate. The desiccant was filtered off, and the solvent was evaporated. To a residue (46 mg, 0.12 mmol) weighed from the obtained residue (77 mg, 0.2 mmol) were added 101 potassium carbonate (82 mg, 0.59 mmmol), 219 potassium iodide (2.0 mg, 0.012 mmol), 97 N,N-dimethylformamide (1.5 mL) and 220 4-bromotetrahydropyran (33 muL, 0.30 mmol) and the mixture was stirred at 100C overnight. The reaction mixture was neutralized with 0.1% aqueous trifluoroacetic acid solution, and purified by high performance liquid chromatography (water-acetonitrile, each containing 0.1% 41 trifluoroacetic acid) to give the 221 title compound (5 mg, 0.011 mmol, 9.2%). MS (ESI) m/z 470 (M+H)+, 25637-16-5
The synthetic route of 25637-16-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EA Pharma Co., Ltd.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; OKUZUMI, Tatsuya; (110 pag.)EP3412664; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics