New learning discoveries about 40191-32-0

40191-32-0, As the paragraph descriping shows that 40191-32-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40191-32-0,Tetrahydro-2H-pyran-4-carbonyl chloride,as a common compound, the synthetic route is as follows.

Add TEA (51.9 mL, 372.2 mmol) and tetrahydropyran-4-carbonyl chloride (22.1 g, 148.9 mmol) to a mixture of 1-indolin-5-ylethanone (20.0 g, 124.1 mmol) in DCM (496 mL). Stir the resulting mixture at room temperature for two hours. Dilute the reaction mixture with DCM (500 mL) and wash with saturated aqueous sodium bicarbonate. Isolate the organic layer and extract the aqueous layer twice with DCM (500 mL). Wash combined organic layers with saturated aqueous sodium chloride, dry over anhydrous sodium sulfate, filter and concentrate the filtrate to give the title compound quantitatively as a light yellow solid. ES/MS (m/z): 274.0 (M+H). Alternative Isolation Procedure: (0059) Treat the product with heptane and concentrate. Repeat the treatment and concentration a second time. Treat with heptane and cool to 0-5 C. Collect the product by filtration and rinse with heptane and dry to give the title compound.

40191-32-0, As the paragraph descriping shows that 40191-32-0 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; Bastian, Jolie Anne; Chen, Jiehao; Cohen, Jeffrey Daniel; Henry, James Robert; McMillen, William Thomas; Reaman, Bradley Earl; Rubio, Almudena; Sall, Daniel Jon; Zhao, Gaiying; (36 pag.)US2017/354641; (2017); A1;,
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Some tips on 1197-66-6

1197-66-6, The synthetic route of 1197-66-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1197-66-6,2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one,as a common compound, the synthetic route is as follows.

4,4,6,6-Tetramethyl-4H,6H,7H-pyrano[4,3-d] [l,3]thiazol-2-amine A solution of 2,2,6,6-tetramethyloxan-4-one (250 mg,l .60 mmol), pyrrolidine (125 mg, 1.76 mmol) andpTSA (15 mg, 0.08 mmol) in cyclohexane (2 mL) was refiuxed for 2 h. The solvent was removed and replaced by MeOH (0.5 mL) and then sulfur was added (51 mg, 0.20 mmol) followed by cyanamide (74 mg, 1.76 mmol). The solution was refiuxed for 2 h, cooled, diluted with EtOAc and filtered. The filtrate was adsorbed onto silica gel and purified by FCC (eluent: EtOAc: Heptane (0-100%) to afford the title compound as a yellow solid (210 mg, 62% yield); m/z = 213.0 (MH)+.

1197-66-6, The synthetic route of 1197-66-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACTIVE BIOTECH AB; WELLMAR, Ulf; EAST, Stephen; BAINBRIDGE, Marie; MACKINNON, Colin; CARR, James; HARGRAVE, Jonathan; (296 pag.)WO2016/42172; (2016); A1;,
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Downstream synthetic route of 28244-94-2

As the paragraph descriping shows that 28244-94-2 is playing an increasingly important role.

28244-94-2, 4-Methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-¦Â-D-glucopyranoside is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,28244-94-2

General procedure: Glycosyl sulfide (0.25 mmol) and urea hydrogen peroxide (1.5 equiv) was stirred inacetic acid (2.5 mL) at room temperature for 5 minutes and heated at 60 C for 1.5-2.5hour (as per Table 2 in the manuscript). After completion, the reaction mixture wascooled to room temperature and diluted with EtOAc (30 ml). The organic layer waswashed with saturated NaHCO3 followed by brine solution and dried over anhydrousNa2SO4. Further, the organic layer was evaporated and purified in columnchromatography to obtain the corresponding glycosyl sulfoxides.

As the paragraph descriping shows that 28244-94-2 is playing an increasingly important role.

Reference£º
Article; Singh, Adesh Kumar; Tiwari, Varsha; Mishra, Kunj Bihari; Gupta, Surabhi; Kandasamy, Jeyakumar; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1139 – 1144;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 108-55-4

108-55-4, As the paragraph descriping shows that 108-55-4 is playing an increasingly important role.

108-55-4, Dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A flask was charged with AlCl3 (96.38 mmol, 12.85 g, 2.2 equiv) and dry benzene (20 ml) under calcium chloride guard tube and the formed suspension was stirred on ice bath. Subsequently, a solution of glutaric anhydride 10 (43.8 mmol, 5.00 g) in dry benzene (40 ml) was added dropwise over 30 minutes (t < 8 C). The cooling bath was removed and the resulting mixture was stirred at room temperature for 19 hours. The mixture was carefully quenched with water (95 ml) and conc. H2SO4 (10 ml), the aqueous layer was extracted with ethyl acetate (1 x 200 ml, 3 x 50 ml), the combined organics were dried over Na2SO4, filtered and concentrated. The crude product was crystallized from ethyl acetate to yield 5-oxo-5-phenylpentanoic acid (7.00 g, 83%) as a yellow-brown powder;1 mp 124-125 C; 1H NMR (300 MHz, acetone-d6): delta = 1.99 (m, 2H), 2.44 (t, J = 7.2 Hz, 2H), 3.13 (t, J = 7.2 Hz, 2H), 7.51 (m, 2H), 7.62 (m, 1H), 8.01 (d, J = 7.8 Hz, 2H), 10.56 (bs, 1H). 5-Oxo-5-phenylpentanoic acid (26.1 mmol, 5.02 g), paraformaldehyde (78.3 mmol, 2.35 g, 3.0 equiv) and piperidine (5.3 mmol, 0.52 ml, 0.2 equiv) were dissolved/suspended in pyridine (22 ml) and stirred at 70 C for 21 hours. Afterwards, the mixture was poured into 3M H2SO4 (100 ml), the aqueous layer was extracted with ethyl acetate (3 x 100 ml), the combined organics were dried over Na2SO4, filtered and concentrated. The residue was redissolved in CH2Cl2 (100 ml) and extracted with a mixture of half-saturated aqueous NaHCO3 (300 ml) and 2M NaOH (20 ml). The extraction was repeated with half-saturated aqueous NaHCO3 (50 ml). The combined aqueous solutions were washed with CH2Cl2 (2 x 50 ml) and afterwards acidified with conc. H2SO4 to pH = 1-2 and extracted with ethyl acetate (1 x 100 ml, 3 x 70 ml). The combined organics were dried over Na2SO4, filtered and concentrated to give 4-benzoylpent-4-enoic acid 9a (4.60 g, 86%) as a yellow solid; mp 45-46 C; 1H NMR (300 MHz, CDCl3): delta = 2.63 (t, J = 7.2 Hz, 2H), 2.81 (t, J = 7.2 Hz, 2H), 5.69 (s, 1H), 5.94 (s,1H), 7.43 (m, 2H), 7.54 (m, 1H), 7.72 (d, J = 6.9 Hz, 2H), 11.39 (bs, 1H); 13C NMR (75 MHz, CDCl3): delta = 27.2, 32.6, 127.2, 128.2, 129.4, 132.3, 137.5, 145.9, 179.0, 197.8. 108-55-4, As the paragraph descriping shows that 108-55-4 is playing an increasingly important role.

Reference£º
Article; Sivak, Ivan; Berke?, Du?an; Ko?i?ek, Jozef; Kolarovi?, Andrej; Tetrahedron Letters; vol. 57; 10; (2016); p. 1079 – 1082;,
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New learning discoveries about 4677-18-3

As the paragraph descriping shows that 4677-18-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-18-3,2-(Tetrahydro-2H-pyran-4-yl)ethanol,as a common compound, the synthetic route is as follows.,4677-18-3

To a solution of Intermediate I, 4,6-dichloro-2-(methylsulfonyl)pyrimidine (113 mg, 0.5 mmol) in THF (5 ml), was added NaH (14 mg, 0.64mmol) and the solution cooled to -78C. 2- (tetrahydro-2H-pyran-4-yl)ethan-1-ol (65mg) was added dropwise as a solution in THF (lml), and the solution stirred for lh at -78C, then quenched with water, extracted with EtOAc, dried (Mg504), filtered, evaporated and purified by silica gel chromatography (hexane / EtOAc) to give 65 mg of 4-(2-(3,5-dichlorophenoxy)ethyl)tetrahydro-2H-pyran. This was dissolved in DMF (3 ml), NaH (9 mg) was added, followed by 5-(3-methoxyphenyl)-1H-pyrazole (41 mg) and the reaction mixture stirred for lh at RT. Morpholine (21u1) was added, and the reaction stirred overnight at rt, then quenched with water, extracted with EtOAc, dried (Mg504), filtered, evaporated and purified by LC/MS to give 9 mg of 4-(6-(3-(3-methoxyphenyl)-1H-pyrazol-1-yl)- 2-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)pyrimidin-4-yl)morpholine, Compound 3. LC/MS (mobile phase 5-100% ACN in 5 mi, Rt = 4.14 mi (M+H) 466

As the paragraph descriping shows that 4677-18-3 is playing an increasingly important role.

Reference£º
Patent; ACURASTEM INC.; SMRCINA, Martin; LI, Ronghua; NAIR, Anil; AUGUST, Paul; BJERGARDE, Kirsten; (94 pag.)WO2019/46316; (2019); A1;,
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Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 2081-44-9

2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.

2081-44-9, Tetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydropyran-4-ol (15.0 g, 146 mmol, 14.71 mL) in dichloromethane (600 mL) was added PPh3 (50.0 g, 191 mmol) and imidazole (15.0 g, 220 mmol). The mixture was stirred at 0 C and iodine (44.7 g, 176 mmol) was added in portions under a nitrogen atmosphere. Finally, the mixture was stirred at 15 C for 16 hours. On completion, the reaction mixture was filtered and the filtrate was concentrated in vacuo to get a residue. The residue was diluted with water (150 mL) and extracted with ethyl acetate (3 ¡Á 150 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a residue. The residue was purified by column chromatography (petroleum ether: dichloromethane = 1:0 to 2:1) to give the title compound (16.0 g, 51% yield) as a colorless oil.1H NMR (400MHz, CDCl3) delta = 4.48 – 4.41 (m, 1H), 3.80 (td, J = 4.4, 11.6 Hz, 2H), 3.56 – 3.46 (m, 2H), 2.20 – 2.09 (m, 4H).

2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 83-87-4

As the paragraph descriping shows that 83-87-4 is playing an increasingly important role.

83-87-4, (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of peracetylated sugars (a-o) (1.28 mmol) in CH2Cl2 (7 mL) was slowly treated with33% (w/w) HBr in AcOH and was stirred to react for 3 h at room temperature. The reactionmixture was diluted with CH2Cl2 and washed with ice water, saturated NaHCO3 and watersuccessively. The resulting solution was dried over anhydrous Na2SO4 and then concentratedunder reduced pressure. The crude 1-bromo-peracetylated glycosyl donors (1a-1o) were obtainedand used without further purification., 83-87-4

As the paragraph descriping shows that 83-87-4 is playing an increasingly important role.

Reference£º
Article; Li, Xiao-san; Ren, Yi-chang; Bao, Yu-zhou; Liu, Jie; Zhang, Xiao-kun; Zhang, You-wei; Sun, Xue-Long; Yao, Xin-sheng; Tang, Jin-Shan; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 252 – 262;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 951127-25-6

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 1 (2.5 g, 7.64 mmol) was added to toluene (40 mL)Morpholine (1.30 g, 15.30 mmol) was added, heated to 138 C and refluxed with water separator,The reaction was carried out for 6 hours.The reaction solution was allowed to cool to room temperature, the solid was precipitated, the filter was removed,A white solid 33b (2.1 g, yield 70%) was obtained., 951127-25-6

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 53911-68-5

As the paragraph descriping shows that 53911-68-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53911-68-5,4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.,53911-68-5

The solution of commercial 4,5-dichloro-1,2-phenylenediamine (0.36 g) and triethyl amine (0.32 ml) in 1,4-dioxane (1.5 ml) was added to a solution of 3-(4-chlorophenyl)glutaric anhydride (0.45 g) in 1,4-dioxane (1 ml) with ice cooling. The resulting mixture was stirred at rt for 0.5 h and at 40 C. for 0.5 h. Again under ice cooling 1M HCl (3 ml) was added dropwise. A gummy precipitate is formed. After 0.5 h of cooling the aqueous layer is removed by decantation and the residue is dissolved in methanol. The dark solution is decolourised with activated carbon, filtered, and the filtrate concentrated in vacuo. The amorphous solid is redissolved in ethanol (6 ml) and conc. HCl (2 ml) and stirred at reflux for 16 h. After cooling to rt the pH is adjusted to 8 by addition of first NaOH solution, then sat. sodium bicarbonate solution. The aqueous layer is extracted with dichloromethane (40 ml) and the organic layer is washed with sat. sodium chloride solution and dried (sodium sulfate). After concentration the crude (0.46 g) is purified by flash chromatography ((dichloromethane /2% methanol /1% triethyl amine) on silica gel to afford ethyl 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (0.33 g) as yellowish, amorphous solid

As the paragraph descriping shows that 53911-68-5 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITAET DES SAARLANDES; US2012/46307; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 33821-94-2

33821-94-2 2-(3-Bromopropoxy)tetrahydro-2H-pyran 2777988, aTetrahydropyrans compound, is more and more widely used in various fields.

33821-94-2, 2-(3-Bromopropoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-bromo-3-hydroxybenzaldehyde (5.18 g, 25.0 mmol) and 2-(3-bromopropoxy)tetrahydro-2H-pyran (5.1 mL, 30 mmol) in DMF (60 mL) was added sodium hydride (1.20 g, 30.0 mmol) at O0C under nitrogen atmosphere, and the mixture was stirred at room temperature for overnight. The reaction was quenched with water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water twice and brine, and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (9:1 to 3:1 hexane/ethyl acetate) to give 2-bromo-3-[3- (tetrahydropyran-2-yloxy)propoxy]benzaldehyde (8.75 g, quantitative)., 33821-94-2

33821-94-2 2-(3-Bromopropoxy)tetrahydro-2H-pyran 2777988, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ANACOR PHARMACEUTICALS, INC.; WO2008/157726; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics