23462-75-1, Dihydro-2H-pyran-3(4H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,23462-75-1
A 50 mL 3-neck flask with inert gas valve and septum was charged 1.318 g (9.684 mmol) benzohydrazide and 15 mL EtOH. (1.04 g, 10.20 mmol) dihydro-2H-pyran-3(4H)-one was syringed into the flask. Suspension became clear solution after the temperature reaches 60 oC. The mixture tempearture keeps at 60 oC for 7h until benzohydrazide was completely consumed as monitored by GC-MS. White precipitate developed after the temperature was cooled down to RT. The solid was filtered and washed with 1:1 mixture of EtOAc/hexanes. Extra product was obtained by purifying the filtrate on silica column using EtOAc. Total product of 1.76 g was obtained as white solid in 82 % yield. 1H NMR (400 MHz, CDCl3 : 7.56 (br s, 1H), 7.80-7.82 (m, 2H), 7.52-7.56 (m, 1H), 7.44-7.48 (m, 2H), 4.31 (br s, 2H), 3.79-3.85 (t, J = 5.2 Hz, 2H), 2.54-2.57 (t, J = 6.6 Hz, 2H), 1.89-1.95 (quint, J = 6.4 Hz, 2H); 13C NMR (100 MHz, CDCl3): 164.24, 156.49, 133.33, 131.92, 128.68, 127.26, 71.40, 67.14, 24.96, 24.22; HRMS for [C12H14N2O2+H+]: observed 219.1142, calculated 219.1128.
As the paragraph descriping shows that 23462-75-1 is playing an increasingly important role.
Reference£º
Article; Haddad, Nizar; Qu, Bo; Rodriguez, Sonia; Van Der Veen, Lars; Reeves, Diana C.; Gonnella, Nina C.; Lee, Heewon; Grinberg, Nelu; Ma, Shengli; Krishnamurthy, Dhileepkumar; Wunberg, Tobias; Senanayake, Chris H.; Tetrahedron Letters; vol. 52; 29; (2011); p. 3718 – 3722;,
Tetrahydropyran – Wikipedia
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