New learning discoveries about 85064-61-5

As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

85064-61-5, General procedure: N,N-Diisopropylethylamine (132 mL), 4-hydroxycyclohexane-1-carboxylic acid (33 mg) and propylphosphonicanhydride (1.6 mol/L N,N-dimethylformamide solution, 238 mL) were added to a solution of the compound (50 mg)obtained in Reference Example 14-1 in N,N-dimethylformamide (2 mL), and the mixture was stirred at room temperatureovernight. The mixture was purified by preparative LC-MS to give the title compound (Example 3-2) (25 mg) which wasa trans isomer as a highly polar compound, as a colorless amorphous substance.1H NMR (500 MHz, DMSO-d6) delta ppm 1.09 – 2.03 (m, 14.5 H) 2.85 – 2.98 (m, 0.5 H) 3.00 – 3.20 (m, 1.5 H) 3.21 – 3.40(m, 1 H) 3.78 – 4.08 (m, 3.5 H) 4.35 – 4.45 (m, 0.5 H) 4.48 – 4.58 (m, 1 H) 6.73 (s, 1 H) 7.36 – 7.96 (m, 3 H) 8.23 – 8.33 (m, 1 H).MS ESI/APCI Multi posi: 385 [M+H]+. The title compound (Example 3-3) (23.7 mg) which was a cis isomer as a less polar compound was obtainedas a colorless amorphous substance.1H NMR (600 MHz, DMSO-d6) delta ppm 1.13 – 2.02 (m, 12 H) 2.45 – 2.63 (m, 1.5 H) 2.84 – 2.95 (m, 0.5 H) 2.99 – 3.17 (m,1 H) 3.26 – 3.37 (m, 1 H) 3.71 – 4.09 (m, 4.5 H) 4.19 – 4.30 (m, 1 H) 4.38 – 4.46 (m, 0.5 H) 6.73 (br s, 1 H) 7.38 – 7.93(m, 3 H) 8.24 – 8.35 (m, 1 H). MS ESI/APCI Multi posi: 385 [M+H]+.

As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.

Reference£º
Patent; Taisho Pharmaceutical Co., Ltd.; TANAKA, Hiroaki; BOHNO, Ayako; HAMADA, Makoto; ITO, Yuji; KOBASHI, Yohei; KAWAMURA, Madoka; (235 pag.)EP3418276; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics