Downstream synthetic route of 125552-89-8

125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-(bromomethyl)tetrahydropyran (1.0 g; 5.58 mmol) and sodium hydrogen sulfide (0.44 g; 7.82 mmol) in dimethylformamide (4 ml) is stirred at room temperature for 2 hours. The reaction medium is diluted with ether and acidified by addition of concentrated HCl and then extracted. The organic phases are combined, washed with water, dried over magnesium sulfate, filtered and concentrated to dryness. The bis[(tetrahydropyran-4-yl)methane bisulfide (565.00 mg; 77%) obtained in the form of a clear oil is used directly in the next reaction. (0559) MS: [M+H]=263, 125552-89-8

125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; GALDERMA RESEARCH & DEVELOPMENT; MUSICKI, Branislav; BOUIX-PETER, Claire; OUVRY, Gilles; THOREAU, Etienne; (132 pag.)US2018/170869; (2018); A1;,
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Downstream synthetic route of 5631-96-9

As the paragraph descriping shows that 5631-96-9 is playing an increasingly important role.

5631-96-9, 2-(2-Chloroethoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5631-96-9, 2,3-Dicyanohydroquinone (10.0 g, 0.062 mol), K2CO3 (19.0 g, 0.137 mol), chloride 1 (22.6 g , 0.137 mol), and KI (100 mg) in 200 mL DMF were stirred at 60 C for 48 h, when additional chloride 1 (11.3 g, 0.068 mol, 1.1 equiv) was added. After 48 h, the mixture was poured onto ice (500 g) and filtered to yield a beige solid, which was recrystallized from MeOH to yield dinitrile 2 (14.8 g, 57 %) as a white crystalline solid: IR (neat) numax 2940, 2231 cm-1; 1H NMR (500 MHz, CDCl3) delta 1.54 – 1.80 (m, 12H), 3.53 – 4.28 (m, 12H), 4.71 (br s, 2H), 7.28 (s, 2H); 13C NMR (125 MHz, CDCl3) delta 155.5, 119.1, 113.1, 105.7, 99.4, 70.0, 65.6, 62.5, 30.6, 25.4, 19.5; MALDI-MS calcd. for C22H28N2NaO6: [M + Na]+ 439.5, found: 439.6; ESI-MS calcd. for C44H56N4NaO12: [2M + Na]+ 855.4, found: 854.9. ESI-HRMS calcd. for C22H28N2NaO6: [M + Na]+ 439.184, found: 439.1844; calcd. for C44H56N4NaO12: [2M + Na]+ 855.3787, found: 855.3786.

As the paragraph descriping shows that 5631-96-9 is playing an increasingly important role.

Reference£º
Article; Trivedi, Evan R.; Blumenfeld, Carl M.; Wielgos, Todd; Pokropinski, Sharon; Dande, Prasad; Hai, Ton T.; Barrett, Anthony G.M.; Hoffman, Brian M.; Tetrahedron Letters; vol. 53; 41; (2012); p. 5475 – 5478;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 103260-44-2

103260-44-2 Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate 2773412, aTetrahydropyrans compound, is more and more widely used in various fields.

103260-44-2, Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

103260-44-2, a) 2-Methyl-2-(tetrahydro-pyran-4-yl)-propionic acid ethyl ester; A solution of 1 g (tetrahydro-pyran-4-yl)-acetic acid ethyl ester [103260-44-2] in 3 ml of dry tetrahydrofuran is added dropwise to a solution of lithium dissopropyl amide (freshly prepared from 1 ml diisopropyl amine and 4. 3 ml 1. 6 M butyllithium solution in hexanes) in 5 ml of dry tetrahydrofuran at-78C. The reaction mixture is stirred for 15 minutes at-78C and then 0. 46 mi of methyl iodide are added and the mixture is allowed to warm to 0C over a period of 15 minutes. The reaction mixture is re-cooled to-78C and then a solution of lithium diisopropyl amide (freshly prepared from 1 ml diisopropyl amine and 4. 3 ml 1. 6 M butyllithium solution in hexanes) in 5 ml of dry tetrahydrofuran is added dropwise. The solution is stirred for 15 minutes at-78C and then 0. 46 ml of methyl iodide are added and the mixture is allowed to warm to room temperature. After 2 hours, the reaction mixture is quenched with 20 mi of 1M HO and then extracted with tert-butyl methyl ether (2x). The combined organic phases are washed with brine, dried over sodium sulphate and concentrated by evaporation. The title compound is obtained as a colourless oil from the residue by means of flash chromatography (SiO2 60F). Rf = 0. 27 (1 : 5 EtOAc-heptane)

103260-44-2 Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate 2773412, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; SPEEDEL EXPERIMENTA AG; WO2005/90304; (2005); A1;,
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Simple exploration of 23462-75-1

23462-75-1 Dihydro-2H-pyran-3(4H)-one 90109, aTetrahydropyrans compound, is more and more widely used in various fields.

23462-75-1, Dihydro-2H-pyran-3(4H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1-Synthesis of 3-((trimethylsilyl)ethynyl)tetrahydro-2H-pyran-3-ol A solution of dihydro-2H-pyran-3(4H)-one (200 mg, 2 mmol) in THF was treated with n-BuLi (2 mL) at -78 C. for about 30 min. Ethynyltrimethylsilane (300 mg, 3 mmol) was then added and the reaction mixture was stirred for 3 hr. Purification by gel chromatography afforded the title compound (200 mg, 50%); 1H NMR (400 MHz, DMSO) delta 0.15 (s, 9H), 1.52-1.55 (m, 1H), 1.62-1.67 (m, 1H), 1.80-1.88 (m, 1H), 3.23-3.26 (m, 1H), 3.37-3.44 (m, 1H), 3.49-3.56 (m, 2H), 5.52 (s, 1H)., 23462-75-1

23462-75-1 Dihydro-2H-pyran-3(4H)-one 90109, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 23462-75-1

23462-75-1, 23462-75-1 Dihydro-2H-pyran-3(4H)-one 90109, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23462-75-1,Dihydro-2H-pyran-3(4H)-one,as a common compound, the synthetic route is as follows.

Step 1: The mixture of 38_1 (1.20 g, 11.99 mmol, 1.40 eq) and benzyl N- aminocarbamate (1.42 g, 8.56 mmol, 1.00 eq) in MeOH (15 mL) was stirred at 30C for 2 h. NaBCN (2.69 g, 42.82 mmol, 5.00 eq) was added. The resulting mixture was stirred at 30 C for 16 h. The mixture was concentrated and diluted with water (50 mL) and EA (50 mL). The organic layer was concentrated and purified by column chromatography (PE:EA=10:1~2:1) to give 38_2 (1.50 g, 5.99 mmol, 70% yield) as a colorless oil. LCMS: RT = 0.568 min, m/z 273.2 [M+H]+ NMR (CDCb, 400 MHz) S 7.40-7.35 (m, 5H), 6.25 (s, 1H), 5.26-5.14 (m, 2H), 3.86-3.73 (m, 3H), 3.48-3.30 (m, 2H), 1.91-1.85 (m, 2H), 1.59-1.46(m, 2H).

23462-75-1, 23462-75-1 Dihydro-2H-pyran-3(4H)-one 90109, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD; BEN NERIAH, Yinon; BRACHYA, Guy; BURSTAIN, Ido; MINZEL, Waleed; SNIR-ALKALAY, Irit; VACCA, Joseph; LI, Dansu; (129 pag.)WO2017/21969; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 14774-37-9

14774-37-9, 14774-37-9 Tetrahydropyran-4-methanol 2773573, aTetrahydropyrans compound, is more and more widely used in various fields.

14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 203A (tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate To a solution of tetrahydro-2H-pyran-4-ylmethanol (Combi-Blocks, 2.0 g, 17.2 mmol) in 10 mL of of CH2Cl2 and 10 mL of of pyridine was added p-toluenesulfonyl chloride (3.5 g, 18.1 mmol) in portions over 15 minutes. The mixture stirred at ambient temperature for 16 hours and was quenched with 10 mL of saturated, aqueous NaHCO3. The layers were separated and the aqueous layer was extracted with three 10 mL portions of CH2Cl2. The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound. 1H NMR (300 MHz, dimethylsulfoxide-d6) delta ppm 1.05-1.25 (m, 2 H), 1.40-1.53 (m, 2 H), 1.73-1.94 (m, 1 H), 2.43 (s, 3 H), 3.14-3.28 (m, 2 H), 3.71-3.84 (m, 2 H), 3.88 (d, J=6.4 Hz, 2 H), 7.48 (d, J=8.5 Hz, 2 H), 7.79 (d, J=8.5 Hz, 2 H); MS (DCI/NH3) m/z 288 (M+NH4)+.

14774-37-9, 14774-37-9 Tetrahydropyran-4-methanol 2773573, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Florjancic, Alan S.; Dart, Michael J.; Ryther, Keith B.; Perez-Medrano, Arturo; Carroll, William A.; Patel, Meena V.; Tietje, Karin Rosemarie; Li, Tongmei; Kolasa, Teodozyj; Gallagher, Megan E.; Peddi, Sridhar; Frost, Jennifer M.; Nelson, Derek W.; US2008/58335; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 130290-79-8

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various fields.

130290-79-8, (Tetrahydro-2H-pyran-4-yl)methanamine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-chloro-3-nitrobenzene-1-sulfonamide (100 g), 4-cyano-tetrahydropyran(97.4 mL), and N,N- diisopropylethylamine (160 mL)were heated in acetonitrile to 70C for 24 hours. After coolingto 55 C,t he reaction mixture was distilled at 55 C to remove s olvent until two reaction mass volumes remained. Water (800 mL) was added to the reaction and stirred 1 hour. The reaction mixture was filtered and the solid was washed with water (200 mL), followed by acetonitrile (300 mL) and ethyl acetate (300 mL). The solid was dried under vacuum at 55C for 4 hours. (60g, Yield: 0.6w/w)., 130290-79-8

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 1197-66-6

1197-66-6, As the paragraph descriping shows that 1197-66-6 is playing an increasingly important role.

1197-66-6, 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2. 2,2,6,64etrarnethy1tetrahydro-2Hpyran4carbonitrile: To a stirred solution of2,2,6,6-tetramethyldihydro-2H-pyran-43H)-one (30 g, 0.192 mol) in dimcthoxyethane(400 mE) was added tosylmethyl isoeyanide (48.7 g, 0,249 eq) followed by the addition oftert-butyiaieoholG4.i g. 0.326) at room temperature. The reaction mixture was cooled to0 C followed by portion-wise addition of potassium tcrt-butoxidc (53.8 g, 0.48 mol). itwas stirred at room temperature for 12 h. The reaction mixture was filtered after dilution with diethyl ether at 0 C and the residue was further washed with diethyl ether. The resultant filtrate was concentrated to provide the title compound as a yellow semi-solid (22 g, 68%)

1197-66-6, As the paragraph descriping shows that 1197-66-6 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BAKTHAVATCHALAM, Rajagopal; AHMAD, Ishtiyaque; BATTULA, Sivaramakrishna; GIJSEN, Henricus Jacobus Maria; VADIVELU, Saravanan; WALL, Mark; WO2015/23289; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Analyzing the synthesis route of 951127-25-6

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

951127-25-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

9c (0.40 g, 1.23 mmol) was dissolved in dimethylacetamide (5 mL) at room temperature, and intermediate 1 (0.33 g, 1.0 mmol) was added and stirred at room temperature for 1 hour.Sodium tris (acetoxy) borohydride (028 g, 1.3 mmol) was added to the reaction solution and allowed to react at room temperature for 16 hours.The reaction solution was cooled to 0 C, water (20 mL) and aqueous ammonia (2 mL) were successively added to precipitate a white solid.The reaction solution was filtered and the cake was washed successively with water (10 mL x 2), petroleum ether (10 mL x 1).The filter cake was dissolved in dichloromethane (50 mL), dried over anhydrous magnesium sulfate,The filtrate was concentrated under reduced pressure to give a pale yellow solid 9d (0.22 g, yield 45.9%).

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
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New learning discoveries about 125552-89-8

125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.

The compound 3 (300 mg, 0 . 70 mmol, 1.0 eq), dissolved in DMF (3 ml), the compound is added under the room temperature condition 4 (150 mg, 0 . 84 mmol, 1.2 eq), K2CO3(200 Mg, 1 . 40 mmol, 2.0 eq), lidded cooking vessel 100 C reaction 4 hours. TLC plate display the reaction is complete, the crude product of job then turns on lathe, coils over post (PE:EA=4:1), to obtain compound EXP 3 (320 mg, yield: 78%).

125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing Kefeipingshenghui Pharmaceutical Co., Ltd.; Jin Qiu; Qin Yinlin; Su Mei; Qiu Yanan; Lou Yajing; (24 pag.)CN109111435; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics