951127-25-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
9c (0.40 g, 1.23 mmol) was dissolved in dimethylacetamide (5 mL) at room temperature, and intermediate 1 (0.33 g, 1.0 mmol) was added and stirred at room temperature for 1 hour.Sodium tris (acetoxy) borohydride (028 g, 1.3 mmol) was added to the reaction solution and allowed to react at room temperature for 16 hours.The reaction solution was cooled to 0 C, water (20 mL) and aqueous ammonia (2 mL) were successively added to precipitate a white solid.The reaction solution was filtered and the cake was washed successively with water (10 mL x 2), petroleum ether (10 mL x 1).The filter cake was dissolved in dichloromethane (50 mL), dried over anhydrous magnesium sulfate,The filtrate was concentrated under reduced pressure to give a pale yellow solid 9d (0.22 g, yield 45.9%).
The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
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