With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
The compound 3 (300 mg, 0 . 70 mmol, 1.0 eq), dissolved in DMF (3 ml), the compound is added under the room temperature condition 4 (150 mg, 0 . 84 mmol, 1.2 eq), K2CO3(200 Mg, 1 . 40 mmol, 2.0 eq), lidded cooking vessel 100 C reaction 4 hours. TLC plate display the reaction is complete, the crude product of job then turns on lathe, coils over post (PE:EA=4:1), to obtain compound EXP 3 (320 mg, yield: 78%).
125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Nanjing Kefeipingshenghui Pharmaceutical Co., Ltd.; Jin Qiu; Qin Yinlin; Su Mei; Qiu Yanan; Lou Yajing; (24 pag.)CN109111435; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics