New learning discoveries about 125552-89-8

125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.

The compound 3 (300 mg, 0 . 70 mmol, 1.0 eq), dissolved in DMF (3 ml), the compound is added under the room temperature condition 4 (150 mg, 0 . 84 mmol, 1.2 eq), K2CO3(200 Mg, 1 . 40 mmol, 2.0 eq), lidded cooking vessel 100 C reaction 4 hours. TLC plate display the reaction is complete, the crude product of job then turns on lathe, coils over post (PE:EA=4:1), to obtain compound EXP 3 (320 mg, yield: 78%).

125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing Kefeipingshenghui Pharmaceutical Co., Ltd.; Jin Qiu; Qin Yinlin; Su Mei; Qiu Yanan; Lou Yajing; (24 pag.)CN109111435; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics