With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-18-3,2-(Tetrahydro-2H-pyran-4-yl)ethanol,as a common compound, the synthetic route is as follows.,4677-18-3
Step 2: Synthesis of Compound D3To a solution of 1.63 g (12.5 mmol) of compound D2 in pyridine (15 mL) are added 3.58 g (18.8 mmol) of p-toluenesulfonylchloride. The reaction is stirred at room temperature for 5 h. The reaction mixture is concentrated under reduced pressure. The residue is dissolved 2M aqueous HC1 solution (20 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts are dried over Na2S04, filtered and the solvent is removed to give 1.9 g of compound D3 as off-white crystalline solid. Yield: 53%; ES-MS: m/z 285 [M+H]; 1H-NMR (500 MHz, CHLOROFORM-d) delta ppm 1.17 – 1.29 (2 H, m), 1.45 – 1.52 (2 H, m), 1.57 – 1.67 (3 H, m), 2.46 (3 H, s), 3.32 (2 H, td, 7=11.78, 1.93 Hz), 3.91 (2 H, dd, 7=11.28, 4.13 Hz), 4.08 (2 H, t, 7=6.14 Hz), 7.36 (2 H, d, 7=8.07 Hz), 7.80 (2 H, d, 7=8.44 Hz)
The synthetic route of 4677-18-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; ZINDELL, Renee, M.; ERMANN, Monika; WO2011/109324; (2011); A1;,
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