With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141095-78-5,2-Bromo-1-(tetrahydro-2H-pyran-4-yl)ethanone,as a common compound, the synthetic route is as follows.
Synthesis of 2-((2-chloro-4-(methylamino)pyrimidin-5-yl)oxy)-1-(tetrahydro-2H-pyran-4-yl) ethan-1-one To a stirred solution of the 2-chloro-4-(methylamino)pyrimidin-5-ol (3 g, 18.8 mmol) in CH3CN (60 mL) was added cesium carbonate (12.2 g, 37.70 mmol) followed by 2-bromo-1-(tetrahydro-2H-pyran-4-yl) ethan-1-one (3.9 g 18.8 mmol) at 0 C. and stirred for 1 h. After consumption of the starting material (monitored by TLC), the reaction was quenched with a sodium carbonate solution (20 mL) and extracted with EtOAc (2*20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford 2-((2-chloro-4-(methylamino)pyrimidin-5-yl)oxy)-1-(tetrahydro-2H-pyran-4-yl) ethan-1-one (2.5 g) as a yellow solid and used without further purification. LC-MS: 286.1 (M+); (column; X-Select CSH C-18 (50*3.0 mm, 3.5 mum); RT 2.86 min. 0.05% Aq TFA:ACN; 0.8 mL/min); TLC: 30% EtOAc:hexanes (Rf: 0.5)., 141095-78-5
The synthetic route of 141095-78-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FORUM Pharmaceuticals Inc.; Burnett, Duane A.; Bursavich, Matthew Gregory; McRiner, Andrew J.; (484 pag.)US2017/44182; (2017); A1;,
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