With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.
2-ethyl-3-iodopyrazolo[1,5-a]pyridine 2.0 g (7.36mmol), tetrahydro-2H-pyrane-4-carboxamide 1.43 g (11.1mmol, 1.5eq), cuprous iodide (1.47mmol, 0.2eq) 0.28 g, 2,2-dimethyl-1,3-propanediamine (0.6eq) 0.452 g, potassium triphosphate (K3 PO4 ¡¤NH2 O) and 20 ml of xylene(10vol) under a nitrogen atmosphere (14.7mmol, 2.0eq) 3.39 g, 125 degrees temperature in heated, stirred for 18 hours. In the slowly cooled to a temperature of 95, 95 degrees 30 minutes after stirring, the temperature is slowly cooled within the 55 degree. 20 ml water (10vol) is added, the heating is stopped and gradual cooling to room temperature. In addition to the water temperature is sufficiently lowered from 6 ml of concentrated ammonia (3vol) ([35 degrees), for about 1 hour with stirring. The resulting suspension was filtered, washed with 12 ml of water (6vol), the resulting solid was returned to the reaction vessel, 12 ml of water, concentrated ammonia water added was stirred 0.5 hour to about 2 ml (1vol). The resulting suspension was filtered again, the resulting solid was 10 ml water (5vol), followed by 6 ml of ethyl acetate was washed (3vol). The filtration product was dried under reduced pressure, 1.56 g of the subject compound is a white solid, 78percent yield was obtained.
344329-76-6, 344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Eisai R & D Management Co., Ltd.; Hoshino, Takehisa; Sato, Keizo; Shimomura, Naoyuki; (7 pag.)JP2017/100995; (2017); A;,
Tetrahydropyran – Wikipedia
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