Reference of 14215-68-0, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide, molecular formula is C8H15NO6. In a patent, introducing its new discovery.
Chemo-enzymatic approach to access diastereopure alpha-substituted GlcNAc derivatives
The formation of diastereopure alpha-substituted GlcNAc derivatives in a simple and straightforward way is a challenging task. Herein, we report the chemical synthesis of diastereomeric alpha/beta-substituted GlcNAc derivatives under non-anhydrous atmosphere using unprotected GlcNAc, followed by a selective enzymatic hydrolysis step using a bacterial N-acetyl-hexosaminidase to provide only alpha-substituted GlcNAc. This enzyme proved to selectively hydrolyze the beta-anomeric GlcNAc derivatives, while the alpha-anomeric GlcNAc derivatives remained unreacted. The released GlcNAc (and therefore the alpha/beta ratios) could be quantified using a coupled enzymatic assay consisting of GlcNAc 2-epimerase and N-acetyl- mannosamine dehydrogenase in a simple and accurate way.
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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics