Synthetic Route of 3301-94-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 3301-94-8, Name is 6-Butyltetrahydro-2H-pyran-2-one, molecular formula is C9H16O2. In a Article£¬once mentioned of 3301-94-8
New strategies in carbonylation chemistry: The synthesis of delta-lactones from saturated alcohols and CO
This paper describes the delta-carbonylation of saturated alcohols which uses a 1,5-hydrogen-transfer reaction of alkoxyl radicals and subsequent carbonylation at the delta-carbon atoms as the key. The carbonylation reactions of five classes of saturated alcohols, namely, primary alcohols having primary delta-carbons, primary alcohols having secondary delta-carbons, primary alcohols having tertiary delta-carbons, secondary alcohols having primary delta- carbons, secondary alcohols having secondary delta-carbons, were carded out, in which lead tetraacetate (LTA) was used as a one-electron oxidant to generate the alkoxyl radicals. Carbonylation of these saturated alcohols, except for primary alcohols having tertiary delta-carbons, took place to afford delta-lactones in moderate to good yields. The mechanism of the remote carbonylation likely involves (1) alkoxyl radical generation via LTA oxidation of a saturated alcohol, (2) conversion of this alkoxyl radical to a delta-hydroxyalkyl radical by a 1,5-hydrogen-transfer reaction, (3) CO trapping of the delta-hydroxyalkyl radical yielding an acyl radical, and (4) oxidation and cyclization of the acyl radical to give a delta-lactone. A metal salt-free system was also tested for a substrate derived from a tertiary alcohol having a secondary delta- carbon; the photolysis of an alkyl 4-nitrobenzenesulfenate under CO pressures gave a delta-lactone in moderate yield.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 3301-94-8 is helpful to your research., Synthetic Route of 3301-94-8
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics