Electric Literature of 33821-94-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 33821-94-2, Name is 2-(3-Bromopropoxy)tetrahydro-2H-pyran, molecular formula is C8H15BrO2. In a Article£¬once mentioned of 33821-94-2
Design and synthesis of silicon-containing tubulin polymerization inhibitors: Replacement of the ethylene moiety of combretastatin A-4 with a silicon linker
Silicon-containing combretastatin analogs were designed, synthesized and evaluated for stability and biological activities. Among them, compound 31 exhibited strong tubulin polymerization-inhibitory activity and very potent tumor cell growth-inhibitory activity (IC50 = 0.007 muM) in MCF-7 cell proliferation assay. This compound also potently inhibited [ 3H]colchicine binding (90.7% inhibition at 3 muM). These activities were comparable to those of combretastatin A-4 (CA-4) (1). In addition, compound 31 was physico-chemically more stable than 1. These results suggest that a silicon linker can act as a bioisoster of a cis carbon-carbon double bond.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 33821-94-2 is helpful to your research., Electric Literature of 33821-94-2
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics