The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.135643-82-2, Name is Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, molecular formula is C8H14O4. In a Article£¬once mentioned of 135643-82-2, Safety of Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate
Androgen receptor affinity of 5′-acyl furanosteroids
Syntheses of 5′-acyl furanosteroids are described from the corresponding unsubstituted [3,2-b]furanosteroids using acid anhydrides and acid chlorides in the presence or absence of Lewis acids. New methods have been developed to prepare 5′-acetyl derivatives: reduction of a 5′-trichloroacetyl intermediate either by sodium formaldehyde sulfoxylate or with 10% Pd/C. Most of these 5′- acyl derivatives bind to the rat ventral prostate androgen receptor. However the antiandrogenic activity was diminished when compared with 4, 5′- methylsulfonyl furanosteroid. Biological studies revealed that 5′-acyl furanosteroids were either androgens or modest antiandrogens. The electrostatic potential maps of the substructures of 3, 4, and 5′-acetyl syn- and anti-furanosteroids showed striking differences which may explain, to some extent, the lack of significant antiandrogenic activity of 5′-acyl furanosteroids.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of Methyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate, you can also check out more blogs about135643-82-2
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics