In an article, author is Linder, Igor, once mentioned the application of 713-95-1, Name is 6-Heptyltetrahydro-2H-pyran-2-one, molecular formula is C12H22O2, molecular weight is 198.3, MDL number is MFCD00006651, category is Tetrahydropyrans. Now introduce a scientific discovery about this category, Recommanded Product: 6-Heptyltetrahydro-2H-pyran-2-one.
Reaction of Lithiated Propargyl Ethers with Carbonyl Compounds – A Regioselective Route to Furan Derivatives
The deprotonation of 3-aryl-substituted alkyl propargyl ethers with n-butyllithium provides an ambident anion that reacts with carbonyl compounds to provide mixtures of gamma-substituted products with alkoxyallene substructure and of alpha-substituted propargyl ethers. The ratio of the two product types strongly depends on the solvent: in diethyl ether the gamma-substituted products predominate whereas the more polar tetrahydrofuran favors the alpha-adducts. The primary addition products undergo 5-endo-trig or 5-endo-dig cyclizations under various reaction conditions to afford isomeric furan derivatives. The highest selectivity in favor of alpha-substituted products was achieved by employing a MOM-protected propargyl ether. During the protonation step no evidence for a proton shift leading to an isomeric allenyl anion was found. A brief mechanistic discussion tries to rationalize the observed regio-selectivities.
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Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics