Application of 40191-32-0, An article , which mentions 40191-32-0, molecular formula is C6H9ClO2. The compound – Tetrahydro-2H-pyran-4-carbonyl chloride played an important role in people’s production and life.
Acylglycinamides as inhibitors of glycine transporter type 1
A screening hit was used as the basis for the core structure of a new series of acylglycinamide GlyT-1 inhibitors. Investigation of the SAR around four areas of diversity used facile chemistry to prepare compounds quickly. By focussing on reducing the lipophilicity and improving the aqueous solubility in the series we were able to prepare a compound (17e) with a good level of activity at GlyT-1, selectivity over GlyT-2 and moderate oral bioavailability.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 40191-32-0, help many people in the next few years., Application of 40191-32-0
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics