A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 31608-22-7, Name is 2-(4-Bromobutoxy)tetrahydro-2H-pyran, molecular formula is C9H17BrO2. In a Article，once mentioned of 31608-22-7, Product Details of 31608-22-7
Analogues of a bipartite compound, dequalinium (DECA) (quinolinium, 1,1′-(1,10-decanediyl)bis(4-amino-2-methyl diiodide)), were tested for inhibition of protein kinase Calpha (PKCalpha). In vitro assays of monomeric and dimeric analogues support a model in which DECA inhibits PKCalpha by an obligatory two-point contact, a unique mechanism among PKC inhibitors. The presence of unsaturation in the center of the C10-alkyl linker produced geometric isomers with different inhibitory potencies: cis IC50 = 52 ± 12 muM and trans IC50 = 12 ± 3 muM, where the trans isomer was equipotent to that of the saturated C10-DECA. DECA analogues with longer, saturated linkers (C12, C14, or C16) exhibited enhanced inhibitory potencies which reached a plateau with the C14-linker (IC50 = 2.6 ± 0.2 muM). Metastatic melanoma cells treated with 250 nM C12-, C14-, or C16-DECA and irradiated with long-wave UV light (which causes irreversible inhibition of PKCalpha by DECA) confirmed the linker-dependent inhibition of intracellular PKCalpha activity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Product Details of 31608-22-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 31608-22-7, in my other articles.
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics