Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 74808-09-6, C36H36Cl3NO6. A document type is Article, introducing its new discovery., name: (2R,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl 2,2,2-trichloroacetimidate
The glycosyl trichloroacetimidates 1-alpha,beta, 8-alpha, 11-alpha, 13-alpha, 15-alpha, and 17-alpha directly transfer the glycosyl moiety to phosphoric acid mono- and diesters.The acidity of the phosphoric acid derivatives used was sufficient for the activation of the trichloroacetimidates, therefore an additional acidic catalyst was not required.From the beta-imidate 1-beta alpha-glycosyl phosphate and from the alpha-imidates preferentially beta-glycosyl phosphates were obtained.Reaction of dibenzyl phosphate (2a) and cetyl phosphate (2c) with 1-alpha demonstrated that beta/alpha-anomerization iscatalyzed by traces of acid.The glycosyl phosphates 3a-alpha, 3a-beta – 3c-beta, 3f-alpha, 9a-beta, and 9c-beta were partly or totally deprotected.The structures of the synthezised compounds were assigned by 1H NMR spectroscopy and by comparison with literature data.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.name: (2R,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl 2,2,2-trichloroacetimidate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 74808-09-6, in my other articles.
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics