Synthetic Route of 2081-44-9. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Like 2081-44-9, Name is Tetrahydro-2H-pyran-4-ol. In a document type is Patent, introducing its new discovery.
Provided is a compound which is useful as an AMPK activator. A compound represented by formula: wherein L is -NR1-, =N-, -O-, -S-, -SO2-, -CR2R3-, or =CR2-; dashed line indicates the presence or absence of a bond; X is -CR4R5-, or -O-; Y is substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclyl; Z is =CR6-, or =N-; R1 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R4 and R5 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R6 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R7, R8 and R9 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R10 and R11 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; and R12 is hydrogen or substituted or unsubstituted alkyl, or its pharmaceutically acceptable salt.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics