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The present invention relates to pyrimidine derivatives and salts thereof, preparation method and pharmaceutical use thereof. Specifically, the present invention relates to pyrimidine derivatives of general formula(I), pharmaceutically acceptable salts thereof, and the preparation methods thereof, as well as their use as a cancer therapeutic agent, especially their use as a P13K kinase inhibitor, wherein each substitute of general formula(I) is defined as the specification.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics