While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 2081-44-9, Name is Tetrahydro-2H-pyran-4-ol, molecular formula is C5H10O2. In a Patent，once mentioned of 2081-44-9, Recommanded Product: 2081-44-9
The invention relates to 1-isopropyl-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine mono-maleate, and crystalline Form 1 thereof. The invention also provides a process for the preparation of 1-isopropyl-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine (Formula (A)) or a pharmaceutically acceptable salt thereof, which process comprises: (a) reacting a non-acid-chloride derivative of 4-(tetrahydro-2H-pyran-4-yloxy)benzoic acid, in which the carboxylic acid group has been activated, with 1-isopropyl-hexahydro-1H-1,4-diazepine; and (b) optionally preparing a pharmaceutically acceptable salt of 1-isopropyl-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine. Process (a) typically comprises activation of 4-(tetrahydro-2H-pyran-4-yloxy)benzoic acid with a coupling reagent, preferably carbonyl diimidazole, followed by reaction with 1-isopropyl-hexahydro-1H-1,4-diazepine. The invention also provides 1-isopropyl-hexahydro-1H-1,4-diazepine bis-trifluoroacetate. The invention also provides a process for preparing a compound of formula (III) wherein P represents a protecting group.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics