Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In homogeneous catalysis, catalysts are in the same phase as the reactants.3301-94-8, C9H16O2. A document type is Article, introducing its new discovery., HPLC of Formula: C9H16O2
Background: The activity of organophosphorus hydrolase (OPH) that catalyzes the hydrolysis of neurotoxic organo-phosphates (OPs) was reported to evolve from lactonase. Results: In this study, a putative OPH from Acinetobacter sp. (AbOPH) exhibited high lactonase activity with latent OPH activity. Sequence alignment and phylogenetic tree analysis revealed the unique status of AbOPH in evolution. The crystal structure of AbOPH was determined at 2.0 A resolution and a semi-rational design was performed to enhance the OPH activity of AbOPH through a consensus sequence approach. Compared with wild-type AbOPH, which exhibited undetectable activity toward methyl-parathion (MP), the best variant AbOPHI211A showed markedly improved catalytic efficiency (1.1 mumol min?1 mg?1 toward MP. Docking studies suggested that the mutation Ile- 211Ala affects substrate recognition and stabilizesprotein)substrate conformation. Conclusions: This result presents the emergence of new enzyme function by a simple mutation strategy and confirms the high possibility that OPH was evolved from its lactonase ancestor.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics